John E. Mckendrick
University of Reading
15 Papers
146 Citations
John E. Mckendrick is an academic researcher from University of Reading. The author has contributed to research in topics: Metathesis & Bicyclic molecule. The author has an hindex of 7, co-authored 13 publications.
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Papers
Self-assembly of Peptide nanotubes in an organic solvent.
Marta J. Krysmann,Valeria Castelletto,John E. Mckendrick,Luke A. Clifton,Ian W. Hamley,Peter J. F. Harris,Stephen M. King +6 more
TL;DR: The self-assembly of a modified fragment of the amyloid beta peptide extended to give AAKLVFF is studied in methanol, and the secondary structure of the peptide is probed by FTIR and circular dichroism, and UV/visible spectroscopy provides evidence for the important role of aromatic interactions between phenylalanine residues in driving beta-sheet self- assembly.
PEGylated amyloid peptide nanocontainer delivery and release system.
TL;DR: A micellar nanocontainer delivery and release system is designed on the basis of a peptide-polymer conjugate comprising a modified amyloid peptide core surrounded by a PEG corona with considerable potential in the targeted delivery of peptides for therapeutic applications.
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Ring-rearrangement metathesis of bicyclic amino acid derivatives
Simon Maechling,Sarah E. Norman,John E. Mckendrick,Sandeep Basra,Kerstin Köppner,Siegfried Blechert +5 more
TL;DR: The ring-rearrangement metathesis (RRM) of bicyclic amino acid derivatives is of use for the synthesis of constrained amino acid and peptide derivatives with potential as reverse-turn inducers.
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Introduction of 4-Chloro-α-cyanocinnamic Acid Liquid Matrices for High Sensitivity UV-MALDI MS
TL;DR: This paper develops and optimizing an ionic liquid matrix (ILM) and liquid support matrix (LSM) using ClCCA as the principle chromophore and MALDI matrix compound and shows the potential to be a superior alternative to the commonly used and highly successful alpha-cyano-4-hydroxycinnamic acid.
Synthesis and incorporation into cyclic peptides of tolan amino acids and their hydrogenated congeners: construction of an array of A-B-loop mimetics of the Cε3 domain of human IgE.
Daniel A. Offermann,John E. Mckendrick,Jimmy J. P. Sejberg,Bingli Mo,M.D. Holdom,Birgit A. Helm,Robin J. Leatherbarrow,Andrew J. Beavil,Brian J. Sutton,Alan C. Spivey +9 more
TL;DR: The synthesis of an array of conformationally constrained cyclic peptides based on an epitope of the A-B loop within the Cε3 domain of IgE, which is the one predicted by molecular modeling to best mimic the conformation of the native A- B loop epitope in IgE.
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