John E. Duda
University of Pennsylvania
24 Papers
12 Citations
John E. Duda is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Lewy body. The author has an hindex of 13, co-authored 24 publications. Previous affiliations of John E. Duda include Veterans Health Administration.
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Papers
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated
John L. Robinson,Edward B. Lee,Sharon X. Xie,Lior Rennert,EunRan Suh,Colin Bredenberg,Carrie Caswell,Vivianna M. Van Deerlin,Ning Yan,Ahmed Yousef,Howard I. Hurtig,Andrew Siderowf,Murray Grossman,Corey T. McMillan,Bruce L. Miller,John E. Duda,John E. Duda,David J. Irwin,David A. Wolk,Lauren Elman,Leo McCluskey,Alice Chen-Plotkin,Daniel Weintraub,Steven E. Arnold,Johannes Brettschneider,Virginia M.-Y. Lee,John Q. Trojanowski +26 more
TL;DR: The data imply that increased age and APOE ɛ4 status are risk factors for co-pathologies independent of neurodegenerative disease; that neurodegenersative disease severity influences co- Pathology as evidenced by the prevalence of co- pathology in high Alzheimer's disease and neocortical Lewy body disease, but not intermediate Alzheimer’s disease or limbic LewyBody disease.
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Neuropathological and Genetic Correlates of Survival and Dementia Onset in Synucleinopathies: A Retrospective Analysis
David J. Irwin,Murray Grossman,Daniel Weintraub,Daniel Weintraub,Howard I. Hurtig,John E. Duda,John E. Duda,Sharon X. Xie,Edward B. Lee,Vivianna M. Van Deerlin,Oscar L. Lopez,Julia Kofler,Peter T. Nelson,Gregory A. Jicha,Randy Woltjer,Joseph F. Quinn,Joseph F. Quinn,J. A. Kaye,James B. Leverenz,James B. Leverenz,Debby W. Tsuang,Katelan Longfellow,Dora Yearout,Walter A. Kukull,C. Dirk Keene,Thomas J. Montine,Thomas J. Montine,Cyrus P. Zabetian,John Q. Trojanowski +28 more
TL;DR: Cerebral neurofibrillary tangles burden, in addition to α-synuclein pathology and amyloid plaque pathology, are the strongest pathological predictors of a shorter interval between onset of motor and dementia symptoms and survival.
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders
David G. Coughlin,Sharon X. Xie,Mendy Liang,Andrew Williams,Claire Peterson,Daniel Weintraub,Daniel Weintraub,Corey T. McMillan,David A. Wolk,Rizwan S. Akhtar,Howard I. Hurtig,H. Branch Coslett,Roy H. Hamilton,Andrew Siderowf,John E. Duda,John E. Duda,Katya Rascovsky,Edward B. Lee,Virginia M.-Y. Lee,Murray Grossman,John Q. Trojanowski,David J. Irwin +21 more
TL;DR: Using digital histology in a large autopsy cohort of Lewy body disorder patients with dementia to test the hypotheses that co‐occurring Alzheimer disease pathology impacts the anatomic distribution of α‐synuclein (SYN) pathology and that co-occurring neocortical tau pathology in LBDs associates with worse cognitive performance and occurs in a pattern differing from AD.
Quantitative assessment of finger tapping characteristics in mild cognitive impairment, Alzheimer’s disease, and Parkinson’s disease
David R. Roalf,Petra Rupert,Dawn Mechanic-Hamilton,Laura Brennan,John E. Duda,John E. Duda,Daniel Weintraub,John Q. Trojanowski,David A. Wolk,Paul J. Moberg,Paul J. Moberg +10 more
TL;DR: Disease-specific changes in fine motor function occur in the most common neurodegenerative diseases, and the findings suggest that alterations in finger tapping patterns are common in AD, MCI, and PD.
Rapid neuroinflammatory response localized to injured neurons after diffuse traumatic brain injury in swine.
Kathryn L. Wofford,Kathryn L. Wofford,Kathryn L. Wofford,James P. Harris,James P. Harris,Kevin D. Browne,Kevin D. Browne,Daniel P. Brown,Daniel P. Brown,Michael R. Grovola,Michael R. Grovola,Constance J. Mietus,John A. Wolf,John A. Wolf,John E. Duda,John E. Duda,Mary E. Putt,Kara L. Spiller,D. Kacy Cullen,D. Kacy Cullen +19 more
TL;DR: Results indicate that neuronal trauma rapidly activates microglia in a highly localized manner, and suggest that activatedmicroglia may rapidly influence neuronal stability and/or pathophysiology after diffuse TBI.
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