John E. Doe
Syngenta
21 Papers
200 Citations
John E. Doe is an academic researcher from Syngenta. The author has contributed to research in topics: Risk assessment & Medicine. The author has an hindex of 14, co-authored 17 publications.
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Papers
IPCS framework for analyzing the relevance of a noncancer mode of action for humans.
Alan R. Boobis,John E. Doe,Barbara Heinrich-Hirsch,M. E. Meek,Sharon Munn,Mathuros Ruchirawat,Josef Schlatter,Jennifer Seed,Carolyn Vickers +8 more
TL;DR: This work has now been extended to noncancer effects, with the eventual objective of harmonizing framework approaches to both cancer and noncancer endpoints.
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Risk assessment in the 21st century: Roadmap and matrix
Michelle R. Embry,Ammie N. Bachman,David R. Bell,Alan R. Boobis,Samuel M. Cohen,Michael Dellarco,Ian C. Dewhurst,Nancy G. Doerrer,Ronald N. Hines,Angelo Moretto,Timothy P. Pastoor,Richard D. Phillips,J. Craig Rowlands,Jennifer Y. Tanir,Douglas C. Wolf,John E. Doe +15 more
TL;DR: The RISK21 integrated evaluation strategy is a problem formulation-based exposure-driven risk assessment roadmap that takes advantage of existing information to graphically represent the intersection of exposure and toxicity data on a highly visual matrix.
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A 21st century roadmap for human health risk assessment.
Timothy P. Pastoor,Ammie N. Bachman,David R. Bell,Samuel M. Cohen,Michael Dellarco,Ian C. Dewhurst,John E. Doe,Nancy G. Doerrer,Michelle R. Embry,Ronald N. Hines,Angelo Moretto,Richard D. Phillips,J. Craig Rowlands,Jennifer Y. Tanir,Douglas C. Wolf,Alan R. Boobis +15 more
TL;DR: This paper provides a brief overview of the tiered RISK21 framework called the roadmap and risk visualization matrix, and articulates the core principles derived by RISk21 participants that guided its development.
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A tiered approach to systemic toxicity testing for agricultural chemical safety assessment
John E. Doe,Alan R. Boobis,Ann M. Blacker,Vicki L. Dellarco,Nancy G. Doerrer,Claire Franklin,Jay I. Goodman,Joel M. Kronenberg,Richard Lewis,E. E. McConnell,Thierry Mercier,Angelo Moretto,Canice Nolan,Stephanie Padilla,Whang Phang,Roland Solecki,Lorraine Tilbury,Bennard van Ravenzwaay,Douglas C. Wolf +18 more
TL;DR: The proposed tiered testing approach has the potential to provide new risk assessment information for shorter human exposure durations while reducing the number of animals used and without compromising the sensitivity of the determination of longer term reference doses.
Issues in the design and interpretation of chronic toxicity and carcinogenicity studies in rodents: approaches to dose selection.
Lorenz R. Rhomberg,Karl Baetcke,Jerry N. Blancato,James S. Bus,Samuel M. Cohen,Rory B. Conolly,Rakesh Dixit,John E. Doe,Karen Ekelman,Penny Fenner-Crisp,Paul Harvey,Dale Hattis,Abigail Jacobs,David Jacobson-Kram,Tom Lewandowski,Robert G Liteplo,Olavi Pelkonen,Jerry R. Rice,Diana Somers,Angelo Turturro,Webster West,Stephen S. Olin +21 more
TL;DR: The present report builds on an earlier ILSI RSI working group developed a set of principles for the selection of doses for chronic rodent studies, examining some of the issues that arise and offering new perspectives and approaches for putting the principles into practice.
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