John D. Lafferty
McMaster University
22 Papers
146 Citations
John D. Lafferty is an academic researcher from McMaster University. The author has contributed to research in topics: Thalassemia & Hemoglobinopathy. The author has an hindex of 9, co-authored 22 publications. Previous affiliations of John D. Lafferty include St. Joseph Hospital & Hamilton General Hospital.
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Papers
The evaluation of various mathematical RBC indices and their efficacy in discriminating between thalassemic and non-thalassemic microcytosis.
TL;DR: In this article, five mathematical indices have been proposed as useful for this purpose: Bessman index, Shine and Lai index, England index, Mentzler index, and mean cell volume alone.
Evaluation of a dual hemoglobin A(2)/A(1c) quantitation kit on the bio-rad variant II automated hemoglobin analyzer.
TL;DR: Evaluated dual kit capable of both Hb A(1c) quantitation and hemoglobinopathy investigation on a single kit eliminates the need for extensive kit switch over; improves utility for newborn screening because of its quantification of Hb Barts; and eliminates theneed for separate HB A(2) reference intervals for patients with Hb S.
31
Fetal-maternal hemorrhage detection in Ontario.
TL;DR: A strategy of prescribing an extra 1,500-IU Rho(D) immune globulin dose, in addition to the dose required to treat the volume of fetal blood detected, is an effective strategy to overcome the limitations of FMH quantitation by acid elution.
An algorithm to aid in the investigation of thalassemia trait in multicultural populations.
TL;DR: A high index of suspicion based on ethnic background and low MCV can provide increased sensitivity and specificity for the detection of thalassemia trait in centers with multicultural populations similar to the study population.
16
A Multicenter Trial of the Effectiveness of ζ-Globin Enzyme-Linked Immunosorbent Assay and Hemoglobin H Inclusion Body Screening for the Detection of α0-Thalassemia Trait
John D. Lafferty,David Barth,Brian L. Sheridan,Andrew McFarlane,Linda M. Halchuk,Anne Raby,Mark Crowther,Mark Crowther +7 more
TL;DR: Routine use of the zeta-globin ELISA in combination with a shortened HbH screen will improve the efficacy of prenatal screening for carriers of hemoglobin Bart's hydrops fetalis through improved detection and referral for follow-up DNA testing.