John Crawford
Cambridge University Hospitals NHS Foundation Trust
4 Papers
1 Citations
John Crawford is an academic researcher from Cambridge University Hospitals NHS Foundation Trust. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 1, co-authored 2 publications.
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Papers
Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression
Nuno Rocha,Nuno Rocha,David A Bulger,David A Bulger,David A Bulger,Andrea Frontini,Hannah Titheradge,Sigrid Bjerge Gribsholt,Rachel G. Knox,Rachel G. Knox,Matthew Page,Julie Harris,Julie Harris,Felicity Payne,Claire Adams,Claire Adams,Alison Sleigh,Alison Sleigh,John Crawford,Anette P. Gjesing,Jette Bork-Jensen,Oluf Pedersen,Inês Barroso,Torben Hansen,Helen Cox,Mary M. Reilly,Alexander M. Rossor,Rebecca J. Brown,Simeon I. Taylor,Duncan McHale,Martin Armstrong,Elif A. Oral,Vladimir Saudek,Vladimir Saudek,Stephen O'Rahilly,Stephen O'Rahilly,Eamonn R. Maher,Eamonn R. Maher,Bjørn Richelsen,David B. Savage,David B. Savage,Robert K. Semple,Robert K. Semple +42 more
TL;DR: It is suggested that specific MFN2 mutations cause tissue-selective mitochondrial dysfunction with increased adipocyte proliferation and survival, confirm a novel form of excess adiposity with paradoxical suppression of leptin expression, and suggest potential targeted therapies.
Dipg-49. a systems biology approach to defining and targeting cell state-specific master regulator dependencies in diffuse midline glioma
Ester Calvo Fernandez,Junqiang Wang,Xu Zhang,Hong Jian Wei,H. Minns,Aaron T. Griffin,Aleksandar Obradovic,Lukas Vlahos,Timothy S Martins,Pamela S. Becker,John Crawford,Robyn D. Gartrell,Luca Szalontay,Stergios Zacharoulis,Zhiguo Zhang,Robert J. Wechsler-Reya,Cheng-Chia Wu,Andrea Califano,Jovana Pavisic +18 more
TL;DR: In this paper , the authors used network-based methodologies to dissect the heterogeneity of diffuse midline glioma (DMG) tumors and to discover MR proteins representing pharmacologically accessible, mechanistic determinants of molecularly distinct cell states.
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Author response: Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression
Nuno Rocha,Nuno Rocha,David A Bulger,David A Bulger,David A Bulger,Andrea Frontini,Hannah Titheradge,Sigrid Bjerge Gribsholt,Rachel G. Knox,Rachel G. Knox,Matthew Page,Julie Harris,Julie Harris,Felicity Payne,Claire Adams,Claire Adams,Alison Sleigh,Alison Sleigh,John Crawford,Anette P. Gjesing,Jette Bork-Jensen,Oluf Pedersen,Inês Barroso,Torben Hansen,Helen Cox,Mary M. Reilly,Alexander M. Rossor,Rebecca J. Brown,Simeon I. Taylor,Duncan McHale,Martin Armstrong,Elif A. Oral,Vladimir Saudek,Vladimir Saudek,Stephen O'Rahilly,Stephen O'Rahilly,Eamonn R. Maher,Eamonn R. Maher,Bjørn Richelsen,David B. Savage,David B. Savage,Robert K. Semple,Robert K. Semple +42 more
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Abstract 4304: Network-based inference identifies cell state-specific drugs targeting master regulator vulnerabilities in diffuse midline glioma
Ester Calvo Fernandez,Junqiang Wang,Xu Zhang,Hong Jian Wei,H. Minns,Aaron T. Griffin,Lukas Vlahos,T. J. Martins,Pamela S. Becker,John Crawford,Robyn D. Gartrell,Luca Szalontay,Stergios Zacharoulis,Zhiguo Zhang,Robert J. Wechsler-Reya,Cheng-Chia Wu,Andrea Califano,Jovana Pavisic +17 more
TL;DR: Fernandez et al. as mentioned in this paper leveraged network-based methodologies to dissect the heterogeneity of diffuse midline glioma (DMG) tumors and to discover master regulator (MR) proteins representing pharmacologically accessible, mechanistic determinants of molecularly distinct cell states.
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