John C. Whittaker
Grinnell College
248 Papers
2.9K Citations
John C. Whittaker is an academic researcher from Grinnell College. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 64, co-authored 240 publications. Previous affiliations of John C. Whittaker include University of London & University of Bristol.
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Papers
The support of human genetic evidence for approved drug indications
Matthew R. Nelson,Hannah Tipney,Jeffery L. Painter,Judong Shen,Paola Nicoletti,Yufeng Shen,Aris Floratos,Pak C. Sham,Mulin Jun Li,Junwen Wang,Lon R. Cardon,John C. Whittaker,Philippe Sanseau +12 more
TL;DR: It is estimated that selecting genetically supported targets could double the success rate in clinical development, and using the growing wealth of human genetic data to select the best targets and indications should have a measurable impact on the successful development of new drugs.
1.5K
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Daniel I. Swerdlow,Michael V. Holmes,Karoline Kuchenbaecker,Engmann Jel.,Tina Shah,Reecha Sofat,Yiran Guo,C Chung,Anne Peasey,Roman Pfister,Simon P. Mooijaart,Helen Ireland,Maarten Leusink,Claudia Langenberg,KaWah Li,Jutta Palmen,Phil Howard,Jackie A. Cooper,Fotios Drenos,John Hardy,Mike A. Nalls,Yun Li,Gordon D.O. Lowe,Marlene C. W. Stewart,S. J. Bielinski,Julian Peto,Nicholas J. Timpson,John Gallacher,Malcolm G. Dunlop,Richard S. Houlston,Ian Tomlinson,Ioanna Tzoulaki,Jian'an Luan,Boer Jma.,Nita G. Forouhi,N. C. Onland-Moret,Y. T. van der Schouw,Renate B. Schnabel,Jaroslav A. Hubacek,Růžena Kubínová,Migle Baceviciene,Abdonas Tamosiunas,Andrzej Pajak,Roman Topor-Madry,Sofia Malyutina,Damiano Baldassarre,Bengt Sennblad,Elena Tremoli,U de Faire,Luigi Ferrucci,S Bandenelli,Tetsu Tanaka,James F. Meschia,AB Singleton,Gerjan Navis,I. Mateo Leach,Bakker Sjl.,Ron T. Gansevoort,Ian Ford,Stephen E. Epstein,Mary-Susan Burnett,Joe Devaney,Johan Wouter Jukema,Westendorp Rgj.,G Jan de Borst,Y. van der Graaf,P A de Jong,Mailand-van der Zee A-H.,Olaf H. Klungel,A. de Boer,P. A. Doevendans,Jeffrey W. Stephens,Charles B. Eaton,Jennifer G. Robinson,JoAnn E. Manson,F G Fowkes,Timothy M. Frayling,Jenna Price,Peter H. Whincup,Richard W Morris,Debbie A Lawlor,George Davey Smith,Yoav Ben-Shlomo,Susan Redline,Leslie A. Lange,Meena Kumari,Nicholas J. Wareham,Verschuren Wmm.,Emelia J. Benjamin,John C. Whittaker,Anders Hamsten,Frank Dudbridge,Delaney Jac.,Andrew Wong,Diana Kuh,Rebecca Hardy,Berta Almoguera Castillo,John Connolly,P. van der Harst,Eric J. Brunner,Michael Marmot,Christina L. Wassel,Steve E. Humphries,P.J. Talmud,Mika Kivimäki,Folkert W. Asselbergs,Mikhail I. Voevoda,Martin Bobak,Hynek Pikhart,James G. Wilson,Hakon Hakonarson,Alexander P. Reiner,Brendan J. Keating,Naveed Sattar,Aroon D. Hingorani,Juan P. Casas +115 more
TL;DR: IL6R blockade could provide a novel therapeutic approach to prevention of coronary heart disease that warrants testing in suitably powered randomised trials and could help to validate and prioritise novel drug targets or to repurpose existing agents and targets for new therapeutic uses.
1.1K
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.
Karani Santhanakrishnan Vimaleswaran,Diane J. Berry,Emmi Tikkanen,Emmi Tikkanen,Stefan Pilz,Stefan Pilz,Linda T. Hiraki,Jason D. Cooper,Zari Dastani,Denise K. Houston,Andrew R. Wood,Liesbeth Vandenput,Lina Zgaga,Lina Zgaga,Laura M. Yerges-Armstrong,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Marika Kaakinen,Marcus E. Kleber,Kurt Lohman,Luigi Ferrucci,Liisa Byberg,Lars Lind,Mattias Lorentzon,Veikko Salomaa,Harry Campbell,Malcolm G. Dunlop,Malcolm G. Dunlop,Braxton D. Mitchell,Karl-Heinz Herzig,Elizabeth A. Streeten,Evropi Theodoratou,Antti Jula,Nicholas J. Wareham,Claes Ohlsson,Timothy M. Frayling,Stephen B. Kritchevsky,Tim D. Spector,J. Brent Richards,J. Brent Richards,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Peter Kraft,Cyrus Cooper,Chris Power,Ruth J. F. Loos,Thomas J. Wang,John C. Whittaker,John C. Whittaker,Aroon D. Hingorani,Elina Hyppönen +52 more
TL;DR: A mendelian randomization study based on data from multiple cohorts conducted by Karani Santhanakrishnan Vimaleswaran and colleagues re-examines the causal nature of the relationship between vitamin D levels and obesity.
An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People
Matthew R. Nelson,Daniel Wegmann,Margaret G. Ehm,Darren Kessner,Pamela L. St. Jean,Claudio J. Verzilli,Judong Shen,Zheng-Zheng Tang,Silviu Alin Bacanu,Dana Fraser,Liling Warren,Jennifer L. Aponte,Matthew Zawistowski,Xiao Liu,Hao Zhang,Yong Zhang,Jun Li,Yun Li,Li Li,Peter Woollard,Simon Topp,Matthew D. Hall,Keith Nangle,Jun Wang,Gonçalo R. Abecasis,Lon R. Cardon,Sebastian Zöllner,John C. Whittaker,Stephanie L. Chissoe,John Novembre,Vincent Mooser +30 more
TL;DR: It is concluded that because of rapid population growth and weak purifying selection, human populations harbor an abundance of rare variants, many of which are deleterious and have relevance to understanding disease risk.
Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts
Karani Santhanakrishnan Vimaleswaran,Diane J. Berry,Chen Lu,Emmi Tikkanen,Stefan Pilz,Linda T. Hiraki,Jason D. Cooper,Zari Dastani,Rui Li,Denise K. Houston,Andrew R. Wood,Karl Michaëlsson,Liesbeth Vandenput,Lina Zgaga,Laura M. Yerges-Armstrong,Mark I. McCarthy,Josée Dupuis,Marika Kaakinen,Marcus E. Kleber,Karen A. Jameson,Nigel K Arden,Olli T. Raitakari,Jorma Viikari,Kurt Lohman,Luigi Ferrucci,Håkan Melhus,Erik Ingelsson,Liisa Byberg,Lars Lind,Mattias Lorentzon,Veikko Salomaa,Harry Campbell,Malcolm G. Dunlop,Braxton D. Mitchell,Karl-Heinz Herzig,Anneli Pouta,Anna-Liisa Hartikainen,Elizabeth A. Streeten,Evropi Theodoratou,Antti Jula,Nicholas J. Wareham,Claes Ohlsson,Timothy M. Frayling,Stephen B. Kritchevsky,Tim D. Spector,J. Brent Richards,Terho Lehtimäki,Willem H. Ouwehand,Peter Kraft,Cyrus Cooper,Winfried Maerz,Chris Power,Ruth J. F. Loos,Thomas J. Wang,Marjo-Riitta Järvelin,John C. Whittaker,Aroon D. Hingorani,Elina Hyppönen +57 more
- 01 Jan 2013
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