John C. Karpie
University of Pittsburgh
6 Papers
231 Citations
John C. Karpie is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Anterior cruciate ligament reconstruction & Medicine. The author has an hindex of 5, co-authored 6 publications.
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Papers
In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage.
Constance R. Chu,Christian H. Coyle,Charleen T. Chu,Michal Szczodry,Venkat Seshadri,John C. Karpie,Kristina M Cieslak,Elise K Pringle +7 more
TL;DR: This in vivo study showing reduced chondrocyte density without cartilage tissue loss six months after a single intra-articular injection of 0.5% bupivacaine suggests bupvacaine toxicity.
221
Lidocaine Exhibits Dose- and Time-Dependent Cytotoxic Effects on Bovine Articular Chondrocytes In Vitro
John C. Karpie,Constance R. Chu +1 more
TL;DR: Results show dose- and time-dependent cytotoxic effects of lidocaine on bovine articular chondrocytes, and suggest that local anesthetics as a class of drugs may negatively affect articular cartilage.
202
Patellar Tendon Anterior Cruciate Ligament Reconstruction in the High-Demand Patient: Evaluation of Autograft Versus Allograft Reconstruction
Randhir Mascarenhas,Michael J. Tranovich,John C. Karpie,James J. Irrgang,Freddie H. Fu,Christopher D. Harner +5 more
TL;DR: Autograft and fresh-frozen allograft patellar tendon anterior cruciate ligament reconstruction exhibit similar patient-reported and objective outcomes in high-demand individuals at 3 to 14 years' follow-up.
58
Optimizing CO2 normalizes pH and enhances chondrocyte viability during cold storage.
Brian N. Dontchos,Christian H. Coyle,Nicholas J. Izzo,Deanna M. Didiano,John C. Karpie,Alison J. Logar,Constance R. Chu +6 more
TL;DR: Data shows that an increase in pH decreased bovine chondrocyte viability when refrigerated at 4°C in DMEM, and that optimization of CO2 normalized pH and improved chondROcytes viability during cold storage in DM EM.
26
Imaging of Articular Cartilage
John C. Karpie,Constance R. Chu +1 more
TL;DR: In this article, the authors proposed a non-invasive visualization of articular cartilage using diffusion tensor imaging (DTI) and optical coherence tomography (OCT).
6