John C. Deacon

TL;DR: It is found that pHLIP effectively delivers PNAs up to ~7 kDa into cells in a pH-dependent manner, and retains its tumor targeting capabilities when linked to cargoes of this size, although the amount delivered is reduced for PNA cargoe greater than ~6 kDa.

TL;DR: It is shown that pHLIP is capable of forming a helix across lipid bilayers of different thicknesses at low pH, and the kinetics of the slow phase of insertion corresponding to the translocation of C-terminal end of the peptide across bilayer, vary approximately twofold, and correlate with bilayer thickness and fluidity.

TL;DR: A pH-Low Insertion Peptide targeted theranostic agent to enable image-guided NP-enhanced radiotherapy using a clinically feasible amount of injected NPs to Imaging the in vivo NP biodistribution and more acidic tumors has the potential for quantitative radiotherapy treatment planning and pre-selecting patients who will likely benefit more from NP radiation enhancement.

TL;DR: In this paper, the authors describe a mammalian muscle cell expression system and the functional analysis of all six recombinant human type II skeletal muscle myosin isoforms, which indicate that they likely have distinct functions in muscle.