John C. Achenbach
Halifax
10 Papers
25 Citations
John C. Achenbach is an academic researcher from Halifax. The author has contributed to research in topics: Biology & Cannabidiol. The author has an hindex of 7, co-authored 10 publications.
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Papers
Antitumor Activity of Abnormal Cannabidiol and Its Analog O-1602 in Taxol-Resistant Preclinical Models of Breast Cancer.
Andrea M. Tomko,Lauren F. O’Leary,Hilary Trask,John C. Achenbach,Steven R. Hall,Kerry B. Goralski,Lee D. Ellis,Denis J. Dupré +7 more
TL;DR: Atypical cannabinoids, like O-1602 and abnormal cannabidiol, exert antitumorigenic effects on paclitaxel-resistant breast cancer cells, which could represent new leads for the development of additional anticancer treatments when resistance to conventional chemotherapy occurs during the treatment of breast and possibly other cancers.
Use of the zebrafish larvae as a model to study cigarette smoke condensate toxicity.
TL;DR: An in vivo model with which to compare the toxicity profiles of smoke condensates from cigarettes with different design features is developed and may provide insights into the development of smoking related disease and could provide a cost-effective, high-throughput platform for the future evaluation of tobacco products.
Molecular characterization of zebrafish embryogenesis via DNA microarrays and multiplatform time course metabolomics studies.
Kelly H. Soanes,John C. Achenbach,Ian W. Burton,Joseph P. M. Hui,Susanne Penny,Tobias K. Karakach +5 more
TL;DR: This work combines information from three bioanalytical platforms, that is, DNA microarrays, (1)H nuclear magnetic resonance, and mass spectrometry (MS)-based metabolomics, to identify and provide insights into the organism's developmental regulators, and reveals that changes in transcript levels at specific developmental stages correlate with previously published data with over 90% accuracy.
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Analysis of the Uptake, Metabolism, and Behavioral Effects of Cannabinoids on Zebrafish Larvae
John C. Achenbach,Jessica A. Hill,Joseph P. M. Hui,Michael G. Morash,Fabrice Berrué,Lee D. Ellis +5 more
TL;DR: This study has shown that both compounds have distinct behavioral patterns and concentration response profiles, and the uptake kinetics observed for each compound appears to correlate with the change in behavior observed in the behavioral assays.
Comparison of the Zebrafish Embryo Toxicity Assay and the General and Behavioral Embryo Toxicity Assay as New Approach Methods for Chemical Screening
TL;DR: In this article, the authors compare the toxicity profiles of 20 compounds for this General and Behavioral Toxicity (GBT) assay to the ZET assay, and show that these two assays applied together can strengthen the use of zebrafish embryos/larvae as standard toxicity testing models.
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