3 Papers
John Belko is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Immune system & Biology. The author has an hindex of 2, co-authored 2 publications.
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Papers
Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2
Teresa Compton,Evelyn A. Kurt-Jones,Karl W. Boehme,John Belko,Eicke Latz,Douglas T. Golenbock,Robert W. Finberg +6 more
TL;DR: It is shown that the pattern recognition receptors Toll-like receptor 2 (TLR2) and CD14 recognize CMV virions and trigger inflammatory cytokine production, suggesting that a membrane receptor recognizes a CMV envelope protein(s), leading to innate immune activation.
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The Role of Toll-Like Receptors in Herpes Simplex Infection in Neonates
Evelyn A. Kurt-Jones,John Belko,Catherine Yu,Peter E. Newburger,Jennifer P. Wang,Melvin Chan,David M. Knipe,Robert W. Finberg +7 more
TL;DR: It is demonstrated that the interaction between TLR2 and herpes simplex virus (HSV)-1-2 leads to the production of cytokines, which may explain the sepsis syndrome that is seen with HSV (and other virus infections) in neonates.
Monogenic Early-Onset Lymphoproliferation and Autoimmunity: The Natural History of STAT3 GOF Syndrome.
Jennifer W. Leiding,Tiphanie P. Vogel,Valentine G.J. Santarlas,Rahul Mhaskar,Madison R. Smith,Alexandre F. Carisey,Alexander Vargas-Hernández,Manuel Silva-Carmona,Maximilian Heeg,Anne Rensing-Ehl,Bénédicte Neven,Jérôme Hadjadj,Sophie Hambleton,Timothy Ronan Leahy,Martin van Hagen,Charlotte Cunningham-Rundles,Cullen M. Dutmer,Svetlana O. Sharapova,Mervi Taskinen,Ignatius Chua,Rosie Hague,Christian Klemann,Larysa Kostyuchenko,Tomohiro Morio,Akaluck Thatayatikom,Ahmet Ozen,Anna Scherbina,Cindy S. Bauer,Sarah E. Flanagan,Eleonora Gambineri,Lisa Giovannini-Chami,Jennifer Heimall,Kathleen E. Sullivan,Eric J. Allenspach,Neil Romberg,Sean Deane,Benjamin T Prince,Melissa J. Rose,John Bohnsack,Talal Mousallem,Rohith Jesudas,Maria Marluce dos Santos Vilela,Michael O'Sullivan,Jana Pachlopnik Schmid,Stepanka Pruhova,Matthew Rees,Helen C. Su,Sami L. Bahna,Safa Baris,Lisa M. Bartnikas,Amy Chang Berger,Tracy A Briggs,S. Brothers,Vanessa Bundy,Alice Y. Chan,Shanmuganathan Chandrakasan,Mette Christiansen,Theresa Cole,Matthew C. Cook,Mukesh Desai,Ute Fischer,David A. Fulcher,Silvanna Gallo,A. Gauthier,Andrew R. Gennery,José G. Marques,Frédéric Gottrand,Bodo Grimbacher,Eyal Grunebaum,Emma Haapaniemi,Sari Hämäläinen,Kaarina Heiskanen,Tarja Heiskanen-Kosma,Hal M. Hoffman,Luis Ignacio Gonzalez-Granado,A. L. Guerreiro,Leena Kainulainen,Ashish R Kumar,Monica G. Lawrence,Carina Levin,Timi Martelius,Olaf Neth,Peter Olbrich,Alejandro Palma,Niraj C. Patel,Tamara C Pozos,Kahn Preece,Saul Oswaldo Lugo Reyes,M.A. Russell,Yael Dinur Schejter,Christine M. Seroogy,Jan Sinclair,Effie Skevofilax,Dan Suan,Daniel Suegeorgz,Paul Szabolcs,Helena Fleck Velasco,Klaus Warnatz,Kelly Walkovich,Austen Worth,Mikko Seppänen,Troy R. Torgerson,Georgios Sogkas,Stephan Ehl,Stuart G. Tangye,Megan A. Cooper,Joshua D. Miller,Lisa R Forbes Satter,Svetlana Aleshkevich,Luis M. Allende,T. Prescott Atkinson,Faranaz Atschekzei,Sezin Aydemir,Utku Aygunes,Vincent Barlogis,Ulrich Baumann,John Belko,Liliana Bezrodnik,Ariane Biebl,Lori Broderick,Nancy Bunin,María Soledad Caldirola,Martin Castelle,Fatih Celmeli,Louis-Marie Charbonnier,Talal A. Chatila,Deepak Chellapandian,Haluk Cokugras,Niall Conlon,Fionnuala Cox,Etienne Crickx,Buket Dalgic,Virgil A. S. H. Dalm,Silvia Danielian,Nerea Domínguez-Pinilla,Tal Dujovny,Mikael Ebbo,Ahmet Eken,Brittany Esty,Alexandre Fabre,Alain Fischer,Mark C. Hannibal,Laura A. Huppert,Marc D. Ikeda,Stephen Jolles,Kent W. Jolly,Neil Jones,Musa Kakakukcu,Maria Kanariou,Elif Karakoc-Aydiner,Theoni Karamantziani,Charikleia Kelaidi,M. J. Keogan,Ayşenur Paç Kısaarslan,Ayca Kiykim,Adam Klocperk,Kosmas Kotsonis,Natalia B. Kuzmenko,Sylvie Leroy,Harry Lesmana,D. Lianou,Hilary Longhurst,Myriam Ricarda Lorenz,Patrick Maffucci,Ania Manson,Sarah Marchal,Marion Malphettes,L. F. Marega,Andrea A. Mauracher,Kornvalee Meesilpavikai,Holly K. Miller,Joy Mombourquette,Noel G. Morgan,Anna Mukhina,Aladjidi Nathalie,Brigitte Nelken,David Nolan,Anna-Carin Norlin,Matías Oleastro,Alper Ozcan,Marlène Pasquet,José R.M. Pegler,Capucine Picard,Sophia Polychronopoulou,Pierre Quartier,Jan Ramakers,Katrina L. Randall,V. Koneti Rao,Allison Sarah Remiker,Géraldine Resin,Peter Richmond,Frédéric Rieux-Laucat,Yulia Rodina,Pierre-Simon Rohrlich,John Sachs,Inga S. Sakovich,Christopher Santarlas,Sinan Sari,Gregory S. Sawicki,Uwe Dr. Schauer,Selma Cecilia Scheffler Mendoza,Oksana Schvetz,Reinhold E. Schmidt,Klaus Schwarz,Anna Sediva,Kyle James Sinclair,Mary Slatter,John W. Sleasman,Katerina Stergiou,Narissara Suratannon,Kayo Tanita,Grace Thompson,Stephen Travis,Timothy David Trojan,Maria Tsinti,Ekrem Unal,Luciano Urdinez,Felisa Vázquez-Gómez,Maria del Carmen Garcia Villa,Michael Weinrich,Mitchell J. Weiss,B. Wright,Ebru Yilmaz,Radana Zachova,Juan F. Quesada +224 more
TL;DR: In this paper , the authors defined the scope, natural history, treatment, and overall survival of a large global cohort of patients with pathogenic STAT3 gain-of-function (GOF) variants.
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