John Barr
19 Papers
188 Citations
John Barr is an academic researcher. The author has contributed to research in topics: Drug carrier & Controlled release. The author has an hindex of 12, co-authored 19 publications.
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Papers
Poly(ortho esters)--from concept to reality.
Jorge Heller,John Barr +1 more
TL;DR: Drug release from solid materials will be illustrated with 5-fluorouacil and bovine serum albumin, and drug release from gel-like materials will been illustrated with mepivacaine, now in Phase II clinical trials as a delivery system to treat post-operative pain.
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Release of BSA from poly(ortho ester) extruded thin strands.
Alexandra Rothen-Weinhold,K. Schwach-Abdellaoui,John Barr,S.Y. Ng,Hui-Rong Shen,Robert Gurny,J. Heller +6 more
TL;DR: In vitro erosion and BSARelease results indicate that after a fairly long lag-time, BSA release and polymer erosion occur concomitantly indicating an erosion-controlled process.
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Control of Molecular Weight for Auto-Catalyzed Poly(ortho ester) Obtained by Polycondensation Reaction
TL;DR: In this paper, the use of n-decanol during the polymerization as a chain stopper allows good control of polymer molecular weight and thermal and viscoelastic properties of such polymers as well as their molecular weight distribution are also reported.
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Optimization of a novel bioerodible device based on auto-catalyzed poly(ortho esters) for controlled delivery of tetracycline to periodontal pocket
TL;DR: This research focuses on developing and characterizing bioerodible formulations based on auto-catalyzed poly(ortho esters) (POExLAy) for modulated release of tetracycline over 2 weeks, designed to be used as an adjunct in the treatment of periodontal diseases.
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Development and applications of injectable poly(ortho esters) for pain control and periodontal treatment.
J. Heller,John Barr,Steve Ng,H.-R. Shen,K. Schwach-Abdellaoui,Robert Gurny,N Vivien-Castioni,Pierre-Jean Loup,P. Baehni,Andrea Mombelli +9 more
TL;DR: Development studies using the TEG polymer aimed at providing a sustained delivery of an analgesic agent to control post-surgical pain are under development and human clinical trials using the decanediol polymer for the treatment of periodontitis are also underway.
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