John B. Seal
University of Chicago
9 Papers
46 Citations
John B. Seal is an academic researcher from University of Chicago. The author has contributed to research in topics: Medicine & Ischemia. The author has an hindex of 8, co-authored 9 publications.
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Papers
Vascular Dysfunction in Ischemia-Reperfusion Injury
John B. Seal,Bruce L. Gewertz +1 more
TL;DR: Recent progress in understanding of the varied phenomena of vascular dysfunction in I/R injury is highlighted and some promising advances in the understanding and application of ischemic preconditioning and other potential therapies are highlighted.
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The Human Microbiome and Surgical Disease
Michael J. Morowitz,Trissa Babrowski,Erica M. Carlisle,Andrea D Olivas,Kathleen S Romanowski,John B. Seal,Donald C. Liu,John C. Alverdy +7 more
TL;DR: What is known about the role of microbes in the pathogenesis of obesity, gastrointestinal malignancies, Crohn disease, and perioperative complications including surgical site infections and sepsis is discussed.
Agent-based dynamic knowledge representation of Pseudomonas aeruginosa virulence activation in the stressed gut: Towards characterizing host-pathogen interactions in gut-derived sepsis
TL;DR: It is suggested that an integrated and iterative heuristic relationship between computational modeling and more traditional laboratory and clinical investigations, with a focus on identifying useful and sufficient degrees of abstraction, will enhance the efficiency and translational productivity of biomedical research.
The molecular Koch's postulates and surgical infection: a view forward.
TL;DR: The only way to make sense out of the last fifty years of molecular biology is to abandon the mechanistic and atomistic ideas of the pre-DNA era and embrace a more organic, cognitive and computational view of cells and genomes.
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New variability in cerebrovascular anatomy determines severity of hippocampal injury following forebrain ischemia in the Mongolian gerbil.
TL;DR: It is found that transient carotid occlusion induces a wide variation in histological injury of the hippocampus, suggesting that Mongolian gerbils currently available in the US have anomalous connections between the vertebral andCarotid circulations.
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