John B. Patterson
Newbury College
14 Papers
1 Citations
John B. Patterson is an academic researcher from Newbury College. The author has contributed to research in topics: Unfolded protein response & XBP1. The author has an hindex of 7, co-authored 14 publications.
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Papers
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy.
Susan E. Logue,Eoghan P. McGrath,Patricia Cleary,Stephanie Greene,Katarzyna Mnich,Aitor Almanza,Eric Chevet,Roisin M. Dwyer,Anup M. Oommen,Patrick Legembre,Florence Godey,Emma C. Madden,Brian Leuzzi,Joanna Obacz,Qingping Zeng,John B. Patterson,Richard Jäger,Adrienne M. Gorman,Afshin Samali +18 more
TL;DR: It is shown that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to confer potent anti-t tumor effects in TNBC.
Pharmacological targeting of the unfolded protein response for disease intervention.
TL;DR: Recent developments in the design and optimization of novel compounds to manipulate UPR signaling and the application of these small molecules in cancers, neurodegeneration and metabolic diseases are discussed.
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Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer
Na Zhao,Jin Cao,Longyong Xu,Qianzi Tang,Lacey E. Dobrolecki,Xiangdong Lv,Manisha Talukdar,Yang Lu,Xiaoran Wang,Dorothy Hu,Qing Shi,Yu Xiang,Yunfei Wang,Xia Liu,Wen Bu,Yi Jiang,Mingzhou Li,Yingyun Gong,Zheng Sun,Haoqiang Ying,Bo Yuan,Xia Lin,Xin-Hua Feng,Xin-Hua Feng,Sean M. Hartig,Feng Li,Haifa Shen,Yiwen Chen,Leng Han,Qingping Zeng,John B. Patterson,Benny Abraham Kaipparettu,Nagireddy Putluri,Frank Sicheri,Jeffrey M. Rosen,Michael T. Lewis,Xi Chen +36 more
TL;DR: It is shown that oncogenic MYC regulates the inositol-requiring enzyme 1/X-box binding protein 1 (XBP1) branch of the UPR in breast cancer via multiple mechanisms, and it is demonstrated that XBP1 is a synthetic lethal partner of MYC.
Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance
Camila Rubio-Patiño,Jozef P. Bossowski,Gian Marco De Donatis,Laura Mondragón,Elodie Villa,Lazaro Emilio Aira,Johanna Chiche,Rana Mhaidly,Cynthia Lebeaupin,Sandrine Marchetti,Konstantinos Voutetakis,Aristotelis Chatziioannou,Florence Castelli,Patricia Lamourette,Emeline Chu-Van,François Fenaille,Tony Avril,Thierry Passeron,John B. Patterson,Els Verhoeyen,Béatrice Bailly-Maitre,Eric Chevet,Jean-Ehrland Ricci +22 more
TL;DR: It is demonstrated that feeding mice a low-protein (Low PROT) isocaloric diet but not aLow CHO diet reduced tumor growth in three independent mouse cancer models, suggesting that a Low PROT diet induces an IRE1α-dependent UPR in cancer cells, enhancing a CD8-mediated T cell response against tumors.
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Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β
Aaron Talty,Shane Deegan,Mila Ljujic,Katarzyna Mnich,Serika D. Naicker,Dagmar Quandt,Dagmar Quandt,Qingping Zeng,John B. Patterson,Adrienne M. Gorman,Matthew D. Griffin,Afshin Samali,Susan E. Logue,Susan E. Logue +13 more
TL;DR: This study demonstrates that IRE1α, a key component of the Unfolded Protein Response, contributes to assembly of the NLRP3 inflammasome and underscores both the importance and potential therapeutic relevance of targeting I RE1α signaling in conditions of excessive inflammaome formation.
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