John B. Jordan
Amgen
21 Papers
141 Citations
John B. Jordan is an academic researcher from Amgen. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Fluorine-19 NMR. The author has an hindex of 15, co-authored 21 publications. Previous affiliations of John B. Jordan include St. Jude Children's Research Hospital & University of Arkansas.
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Papers
Hepcidin revisited, disulfide connectivity, dynamics, and structure.
John B. Jordan,Leszek Poppe,Mitsuru Haniu,Tara Arvedson,Rashid Syed,Vivian S. W. Li,Hiko Kohno,Helen Kim,Paul D. Schnier,Timothy S. Harvey,Les P. Miranda,Janet Cheetham,Barbra Sasu +12 more
TL;DR: NMR studies reveal a new model for hepcidin that, at ambient temperatures, interconverts between two different conformations, which could be individually resolved by temperature variation.
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Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics
Robert G. Brinson,John P. Marino,Frank Delaglio,Luke W. Arbogast,Ryan M. Evans,Anthony J. Kearsley,Geneviève Gingras,Houman Ghasriani,Yves Aubin,Gregory K. Pierens,Xinying Jia,Mehdi Mobli,Hamish G. Grant,David W. Keizer,Kristian Schweimer,Jonas Ståhle,Göran Widmalm,Edward R. Zartler,Chad W. Lawrence,Patrick N. Reardon,John R. Cort,Ping Xu,Feng Ni,Saeko Yanaka,Koichi Kato,Stuart Parnham,Desiree Tsao,Andreas Blomgren,Torgny Rundlöf,Nils Trieloff,Peter Schmieder,Alfred Ross,Ken Skidmore,Kang Chen,David A. Keire,Darón I. Freedberg,Thea Suter-Stahel,Gerhard Wider,Gregor Ilc,Janez Plavec,Scott A. Bradley,Donna M. Baldisseri,Maurício L. Sforça,Ana Carolina de Mattos Zeri,Julie Yu Wei,Christina M. Szabo,Carlos A. Amezcua,John B. Jordan,Mats Wikström +48 more
TL;DR: The 2D-NMR method is shown to provide the measurement reliability needed to move the technique from an emerging technology to a harmonized, routine measurement that can be generally applied with great confidence to high precision assessments of the HOS of mAb-based biotherapeutics.
Fragment Based Drug Discovery: Practical Implementation Based on 19F NMR Spectroscopy
John B. Jordan,Leszek Poppe,Xiaoyang Xia,Alan C. Cheng,Yax Sun,Klaus Michelsen,Heather Eastwood,Paul D. Schnier,Thomas Nixey,Wenge Zhong +9 more
TL;DR: The use of (19)F NMR-based fragment screening in several areas is demonstrated: as a key tool for rapid and sensitive detection of fragment hits, as a method for the rapid development of structure-activity relationship (SAR) on the hit-to-lead path using in-house libraries and/or commercially available compounds, and as a quick and efficient means of assessing target druggability.
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Broadly Protective Protein-Based Pneumococcal Vaccine Composed of Pneumolysin Toxoid–CbpA Peptide Recombinant Fusion Protein
Beth Mann,Justin A. Thornton,Richard J. Heath,Kristin R. Wade,Rodney K. Tweten,Geli Gao,Karim C. El Kasmi,John B. Jordan,Diana M. Mitrea,Richard W. Kriwacki,Jeff Maisonneuve,Mark R. Alderson,Elaine Tuomanen +12 more
TL;DR: Passive and active immunization protected mice from pneumococcal carriage, otitis media, pneumonia, bacteremia, meningitis, and meningococcal sepsis, and the CbpA peptide-L460D pneumolysoid fusion protein was broadly protective against pneumitiscal infection.
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Structural and Biological Identification of Residues on the Surface of NS3 Helicase Required for Optimal Replication of the Hepatitis C Virus
Samuel G. Mackintosh,Jeff Zhiqiang Lu,John B. Jordan,Melody K. Harrison,Bartek Sikora,Suresh D. Sharma,Craig E. Cameron,Kevin D. Raney,Joshua Sakon +8 more
TL;DR: The biological results suggest that the known biochemical properties associated with the helicase activity of NS3h do not reveal all of the likely biological roles of NS2 during HCV replication, which is not reflective of the large reduction in HCV replicative capacity observed in the biological experiment.
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