John B. Denny
University of Texas at San Antonio
5 Papers
86 Citations
John B. Denny is an academic researcher from University of Texas at San Antonio. The author has contributed to research in topics: Long-term potentiation & Saralasin. The author has an hindex of 5, co-authored 5 publications.
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Papers
Calpain inhibitors block long-term potentiation
TL;DR: It is shown that the extracellular application of two newly developed, highly potent calpain inhibitors block LTP in both the Schaffer collateral-CA1 synaptic zone of the rat hippocampal slice and in perforant path-stimulated dentate granule cells in the intact hippocampus.
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Ethanol and diazepam inhibition of hippocampal LTP is mediated by angiotensin II and AT1 receptors
TL;DR: A new role for AII in the brain in the possible mediation of memory deficits associated with alcohol and the benzodiazepines is indicated.
52
Evidence that protein kinase M does not maintain long-term potentiation.
TL;DR: The results suggest that this enzyme is not responsible for the maintenance of LTP, and this conclusion may extend to other protein kinases as well, since staurosporine has been shown to inhibit a variety of these enzymes.
34
Angiotensin II blocks hippocampal long-term potentiation.
TL;DR: A role for AII and AII receptors of unknown function occur in the hippocampal formation and the results reported here suggest a role for these molecules in the control of hippocampal LTP.
Role of angiotensin II and AT1 receptors in hippocampal LTP
TL;DR: Data on LH stimulation indicate that LH AII-containing neurons send axons into the hippocampus that inhibit the induction of LTP, which provides new information on a neurotransmitter involved in the amnesic effects of benzodiazepines and ethanol-induced memory blackouts and testable hypotheses concerning recent observations that angiotensin converting enzyme (ACE) inhibitors elevate mood and improve certain cognitive processes in the elderly.