John Avera
Indiana University
10 Papers
28 Citations
John Avera is an academic researcher from Indiana University. The author has contributed to research in topics: Virus & Antigen. The author has an hindex of 8, co-authored 10 publications.
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Papers
Symmetry Controlled, Genetic Presentation of Bioactive Proteins on the P22 Virus-like Particle Using an External Decoration Protein.
Benjamin Schwarz,Patrick Madden,John Avera,Bridget Gordon,Kyle Larson,Heini M. Miettinen,Masaki Uchida,Ben LaFrance,Gautam Basu,Agnieszka Rynda-Apple,Trevor Douglas +10 more
TL;DR: Dec-mediated presentation offers a robust, modular means of decorating the exposed exterior of the P22 capsid in order to further orchestrate responses to internally functionalized VLPs within biological systems.
Cargo–shell and cargo–cargo couplings govern the mechanics of artificially loaded virus-derived cages
Aida Llauró,Daniel Luque,Daniel Luque,Ethan Edwards,Benes L. Trus,John Avera,David Reguera,Trevor Douglas,Pedro J. de Pablo,José R. Castón +9 more
TL;DR: Atomic force and three-dimensional cryo-electron microscopy provided mechanical and structural information about the physical mechanisms of viral cage stabilization beyond the mere presence/absence of cargos.
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Induction of Antiviral Immune Response through Recognition of the Repeating Subunit Pattern of Viral Capsids Is Toll-Like Receptor 2 Dependent.
Kelly M. Shepardson,Benjamin Schwarz,Kyle Larson,Rachelle V. Morton,John Avera,Kimberly McCoy,Alayna Caffrey,Ann L. Harmsen,Trevor Douglas,Agnieszka Rynda-Apple +9 more
TL;DR: It is found that an initial antiviral immune response is induced by the repeating subunit pattern of virus exteriors (capsids), and thus, induction of this response is independent of viral infection.
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Sortase-Mediated Ligation as a Modular Approach for the Covalent Attachment of Proteins to the Exterior of the Bacteriophage P22 Virus-like Particle
Dustin P. Patterson,Benjamin Schwarz,John Avera,Brian Western,Matthew Hicks,Paul Krugler,Matthew Terra,Masaki Uchida,Kimberly McCoy,Trevor Douglas +9 more
TL;DR: The research presented here describes the development of a modular approach for the covalent attachment of protein domains to the exterior of the versatile bacteriophage P22 virus-like particle (VLP) via a sortase-mediated ligation strategy.
41
The archaeal Dps nanocage targets kidney proximal tubules via glomerular filtration
Masaki Uchida,Bernhard F. Maier,Hitesh Kumar Waghwani,Ekaterina Selivanovitch,S. Louise Pay,John Avera,EJun Yun,Ruben M. Sandoval,Bruce A. Molitoris,Amy Zollman,Trevor Douglas,Takashi Hato +11 more
TL;DR: In this article, the authors showed that DNA-binding protein from starved cells (Dps) is able to cross the glomerular filtration barrier and is endocytosed by the renal proximal tubules.