Tozinameran

Schematic of the microwave-microfluidic sensor. The resonant profile is shifted due to the sample’s dielectric properties when the assay is introduced on the sensing region, analyzed through the vector network analyzer (VNA) [5] 

/pdf/student-medical-summit-online-2022-3qvs8h7v.pdf

Student Medical Summit - Online 2022

BG03 Epidermolysis bullosa-associated verruciform xanthomas: case series and review of the literature Ebunoluwa Oluwole, Jemima Mellerio, John McGrath, Danielle Greenblatt, Eduardo Calonje, Anoud Zidan, Eglantine Lebas and Suzy Leech Birmingham City Hospital, Sandwell and West Birmingham Hospitals NHS Foundation Trust, Birmingham, UK; St John’s Institute of Dermatology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK; Department of Dermatopathology, St John’s Institute of Dermatology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK; and Royal Victoria Infirmary, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK Verruciform xanthomas (VXs) are rare, benign, mucocutaneous lesions characterized by well-demarcated, yellow or orange–red plaques with a pebbled or granular surface. Their aetiology is not clear, but repetitive trauma and chronic inflammation have been suggested. VXs have been reported in a small number of cases of recessive dystrophic epidermolysis bullosa (RDEB), where it may cause diagnostic confusion with squamous cell carcinoma (SCC). We present four additional cases of epidermolysis bullosa-associated cutaneous VXs and describe different therapeutic modalities and response to treatment. The ages of our patients ranged between 19 and 41 years (two males and two females). They presented with papillomatous, orange–red plaques on the back (three patients) and knee (one patient). The lesions developed spontaneously in areas of poor healing and scarred skin, and varied in size with the largest measuring 15 9 10 cm. Histology confirmed VX with the characteristic features of hyperkeratosis, verrucous epithelial hyperplasia, acantholysis and aggregates of foamy histiocytes accompanied by neutrophil infiltrates in the dermis. The four patients were treated with serial cryotherapy, imiquimod 5% cream, clobetasol propionate 0 05% ointment, serial curettage and cautery and mometasone furoate 0 1% ointment. We are monitoring the response to treatment. Chronic inflammation and repeated trauma have been implicated as possible causes of VXs. Repeated skin blistering, wounds and scarring are hallmark features of RDEB, an inherited skin fragility disorder caused by biallelic mutations in the type VII collagen gene COL7A1. VXs have been described in eight previous cases of RDEB but not in other forms of inherited epidermolysis bullosa. VXs arising in this context is clinically relevant as individuals with RDEB, especially the severe form, are at greatly increased risk of developing multiple aggressive primary SCCs that clinically resemble VXs. A variety of modalities have been used to treat RDEB-associated VXs, including surgical excision, topical corticosteroids, topical 5% imiquimod and cryotherapy. The size of lesions arising in RDEB, as in our cases, may limit the feasibility of excision, but cryotherapy and topical steroids appear to be safe and well tolerated. BG04 Exploring the cellular and genetic composition of human basal cell carcinoma at single-cell and spatial resolutions Clarisse Ganier, Nasrat Harun, Xinyi Du-Harpur, Fiona Watt and Magnus Lynch King’s College London, Centre for Stem Cells and Regenerative Medicine, Guy’s Hospital, London, UK Cutaneous basal cell carcinoma (BCC) of the skin is the most common malignancy in humans and represents a paradigm for the understanding of epithelial–mesenchymal interactions in malignancy. It is locally invasive and can require extensive and disfiguring surgery. It has long been speculated that the stromal microenvironment adjacent to BCC differs to that elsewhere in the dermis and is required for growth of the tumour. Here, we analysed the gene expression at the singlecell resolution of eight patients with BCC corresponding to 60 000 cells vs. 20 healthy skin donors corresponding to 120 000 cells. We identified particular dermal cell types such as fibroblasts and pericytes to be more abundant in BCC than in heathy skin. Thus, we analysed these data in combination with spatial transcriptomics using the Visium platform, in order to give additional spatial patterns of cell localization and their gene expression within the tumour microenvironment context at 50 lm resolution. Subsequently, in situ sequencing using a custom panel of 200 probes on the Cartana platform allowed us to define cellular-resolution maps of cell states within these tumours. We found that while the overall identity of cell populations present within the tumour closely mirrors that of normal tissue, there are quantitative differences in the composition of keratinocyte and immune populations and the spatial arrangement of cells differs greatly. These observations were confirmed by RNA FISH and immunostaining. In particular, we observed a characteristic spatial arrangement of fibroblast populations at the interface of the epithelial and mesenchymal elements of the tumour. We hypothesized that this represents a distinct cancer-associated fibroblast cell state and that this is essential for growth and invasion of the tumour. Our findings provide key insights into the cellular landscape of BCC and suggest that the interface between epithelial and mesenchymal elements of the tumour may offer novel therapeutic targets for the treatment of BCC.

BG04: Exploring the cellular and genetic composition of human basal cell carcinoma at single‐cell and spatial resolutions

book 4 Tumori Journal 105(2S) 2. Patient involvement can be utilized in designing of education in cancer rehabilitation Mervi Siekkinen, Ritva Kosklin, Hanna Ilus, Teija Kemppainen, Sirkku Jyrkkiö, Pia Vihinen 3. The innovative social and health care project for the job reintegration of cancer patients “Una Mano” Sara Paltrinieri 4. Patient involvement in the creation of value: prostate and breast cancer case studies Chiara Ariotti 5. Recognizing the expertise of patients and promoting the involvement process Martine Bouyssie 6. Outcome of Patient-Centered Care Survey conducted in Central Europe and targeting patient and caregiver stakeholder groups Laura Del Campo, Olga Sapoznikov, Francesca Traclò, Nicola Di Flora, Francesco De Lorenzo, Silvia Carelli, Alessandro Sproviero and INTENT group 7. How to include the patient’s voice? Camilla Havsteen and Anne Skov Villadsen 8. Patient involvement in Norway Anne Grethe Ryen Hammerstad 9. Patient involvement improves oncologic care in the Maastricht Cancer Center (MUMC+) Bernd Kremer 10. “Give words to what is unspeakable”: empowering parental communication with children regarding cancer and death Francesca Romito 11. The patient-as-partner approach in Clinical Research at Institut Curie Véronique Gillon 12. Reshaping research through patient involvement Patrick Miqueu Scientific Conference 1. In silico dissection of diffuse large B-cell lymphoma microenvironment provides a 45-gene panel for risk stratification Sabino Ciavarella, Maria Carmela Vegliante, Marco Fabbri, Simona De Summa, Federica Melle, Giovanna Motta, Anna Enjuanes, Alessandro Gulino, Stefania Tommasi, Anna Scattone, Alfredo Francesco Zito, Claudio Agostinelli, Umberto Vitolo, Annalisa Chiappella, Elias Campo, Claudio Tripodo, Attilio Guarini, Stefano A. Pileri 2. Opportunities and challenges of early phase clinical studies Caterina Aversa, Johann S. de Bono 3. Alliance Against Cancer: from Italy to Europe Paolo De Paoli, Silvia Careccia, Gennaro Ciliberto, Anna Sapino, Pier Giuseppe Pelicci, Ruggero De Maria 4. The Mediterranean Oncological Alliance Network AMORe (Alleanza Mediterranea Oncologica in Rete): an opportunity and a challenge Antonio Delvino, Giovanni Battista Bochicchio, Nicola Silvestris, Alessandro Sgambato, Gerardo Botti, Elio Borgonovi, Angelo Rosa, Rosa Martino, Pietro Milella, Antonio Colasurdo, Carmine Mariano, Massimo Mancini, Cristiana Mecca, Attilio Bianchi 5. Reflections on a complex topic: the missions: a new tool within Horizon Europe, the European Research and Innovation Programme 2021-2027 Thierry Philip 6. ECCO’s 5 items of advice on EU mission centered cancer activity Philip Poortmans, Richard Price 7. The European Cancer Patient Coalition’s role in securing meaningful patient involvement in Health Technology Assessment Francesco de Lorenzo, Antonella Cardone, Alex Filicevas 8. Data sharing as a continuum to the role of international networks beyond clinical research Denis Lacombe 9. Radiotherapy: seizing the opportunity in cancer care Joanna Kazmierska, Núria Jornet Sala, Michelle Leech, Chiara Gasparotto, Barbara Alicja JereczekFossa, Yolande Lievens, Umberto Ricardi, John Yarnold 10. The essential role of prevention in reducing the cancer burden in Europe: a commentary from Cancer Prevention Europe Carolina Espina, Linda Bauld, Bernardo Bonanni, Hermann Brenner, Karen Brown, Joakim Dillner, Ellen Kampman, Mef Nilbert, Paolo Vineis, Matty P. Weijenberg, Alison Cox, Theo M. de Kok, Daniela Fecht, Giota Mitrou, David C. Muller, Davide Serrano, Karen Steindorf, Hans Storm, Mangesh A. Thorat, Fränzel van Duijnhoven, Elisabete Weiderpass, Joachim Schüz

Abstract book: OECI Oncology Days 2019

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Student Medical Summit - Online 2022

BG04: Exploring the cellular and genetic composition of human basal cell carcinoma at single‐cell and spatial resolutions

Abstract book: OECI Oncology Days 2019