Joerg E. Braun
University of Massachusetts Medical School
26 Papers
78 Citations
Joerg E. Braun is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Gene silencing & Argonaute. The author has an hindex of 17, co-authored 26 publications. Previous affiliations of Joerg E. Braun include Max Planck Society.
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Papers
GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets
TL;DR: It is found that human GW182 proteins recruit the PAN2-PAN3 and CCR4-CAF1-NOT deadenylase complexes through direct interactions with PAN3 and NOT1, respectively, which are critical for silencing and are conserved in D. melanogaster.
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A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation.
Joerg E. Braun,Vincent Truffault,Andreas Boland,Eric Huntzinger,Chung Te Chang,Gabrielle Haas,Gabrielle Haas,Oliver Weichenrieder,Murray Coles,Elisa Izaurralde +9 more
TL;DR: It is shown that XRN1 directly interacts with EDC4 and DCP1 in human and Drosophila melanogaster cells, respectively, and provides a molecular basis for the coupling of decapping to 5′→3′ mRNA degradation.
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Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resultingworkunderthesameorsimilarlicensetothisone.Theworkmustbeattributedbacktotheoriginalauthorand commercial use is not permitted without specific permission.
Eric Huntzinger,Joerg E. Braun,Latifa Zekri,Elisa Izaurralde +3 more
- 01 Jan 2010
TL;DR: It is shown that two regions of GW182 proteins interact with PABPC1: the first contains a PABP‐interacting motif 2 (PAM2; as shown before for TNRC6C) and the second contains the M2 and C‐terminal sequences in the SD.
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A Molecular Link between miRISCs and Deadenylases Provides New Insight into the Mechanism of Gene Silencing by MicroRNAs
TL;DR: These findings shed light on how miRNAs bring about target mRNA degradation and promise to further the understanding of the mechanism of miRNA-mediated repression.
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The C-terminal α–α superhelix of Pat is required for mRNA decapping in metazoa
Joerg E. Braun,Felix Tritschler,Gabrielle Haas,Cátia Igreja,Vincent Truffault,Oliver Weichenrieder,Elisa Izaurralde +6 more
TL;DR: The multiplicity of interactions mediated by Pat‐C suggests that certain of these interactions are mutually exclusive and, therefore, that Pat proteins switch decapping partners allowing transitions between sequential steps in the mRNA decapping pathway.
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