Jody C. Ullery
Vanderbilt University
8 Papers
72 Citations
Jody C. Ullery is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Cholesterol & Cholesteryl ester. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Jody C. Ullery include Vanderbilt University Medical Center.
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Papers
Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems
Simona G. Codreanu,Jody C. Ullery,Jing Zhu,Keri A. Tallman,William N. Beavers,Ned A. Porter,Lawrence J. Marnett,Bing Zhang,Daniel C. Liebler +8 more
TL;DR: Damage occurred selectively across functional protein interaction networks, with the most highly alkylation-susceptible proteins mapping to networks involved in cytoskeletal regulation and being alkylated only at electrophile concentrations that caused significant toxicity.
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Aggregated LDL and lipid dispersions induce lysosomal cholesteryl ester accumulation in macrophage foam cells
TL;DR: It is shown that treatment of THP-1 macrophages with aggregated low density lipoprotein (AggLDL) or CE-rich lipid dispersions (DISP) produced a similar lysosomal accumulation of both FC and CE, which can be attributable to more general mechanisms than just the inhibition of hydrolysis by oxidized lipids.
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Protein Modification by Oxidized Phospholipids and Hydrolytically Released Lipid Electrophiles: Investigating Cellular Responses
TL;DR: The following perspective will discuss the biological importance of lipid electrophile protein adducts including current strategies employed to identify and isolate proteinAdducts of lipid Electrophiles as well as approaches to define cellular signaling mechanisms altered upon exposure to electrophiles.
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Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Linking and Kinase Inhibition.
TL;DR: It is shown that pyruvate kinase (PKM2) is covalently modified by the lipid electrophiles 4-hydroxy-2-nonenal (HNE) and 4-oxo- 2-nonnal (ONE) and that modification of PKM2 by certain electrophile results in kinase inactivation.
RNA-seq data analysis at the gene and CDS levels provides a comprehensive view of transcriptome responses induced by 4-hydroxynonenal
TL;DR: RNA-seq data analysis yielded an informative and comprehensive picture of gradually evolving response networks with increasing HNE doses, from cell protection against oxidative injury at low dose, initiation of cell apoptosis and DNA damage at intermediate dose to significant deregulation of cellular functions at high dose.