Jochen Kreth
German Cancer Research Center
4 Papers
Jochen Kreth is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Tristetraprolin & Transsulfuration. The author has an hindex of 2, co-authored 3 publications. Previous affiliations of Jochen Kreth include Utrecht University.
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Papers
Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin
TL;DR: Evidence is provided that human Not1 in the cytoplasm associates with the C-terminal domain of tristetraprolin (TTP), an RNA binding protein that mediates rapid degradation of mRNAs containing AU-rich elements (AREs).
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis
Hamed Alborzinia,Andrés F. Flórez,Sina Kreth,L.M. Brückner,Umut Yildiz,Moritz Gartlgruber,Dorett I Odoni,Gernot Poschet,Karolina Garbowicz,Chunxuan Shao,Corinna Klein,Jasmin Meier,Petra Zeisberger,Michal Nadler-Holly,Matthias Ziehm,Franziska Paul,Jürgen Burhenne,Emma Bell,Marjan Shaikhkarami,Roberto Würth,Sabine A Stainczyk,Elisa M Wecht,Jochen Kreth,Michael Büttner,Naveed Ishaque,Matthias Schlesner,Barbara Nicke,Carlo Stresemann,Maria Llamazares Prada,Jan H. Reiling,Matthias Fischer,Ido Amit,Matthias Selbach,Carl Herrmann,Stefan Wölfl,Kai Oliver Henrich,Thomas Höfer,Andreas Trumpp,Frank Westermann +38 more
TL;DR: In this article , pharmacological inhibition of both cystine uptake and transsulfuration combined with GPX4 inactivation resulted in tumor remission in an orthotopic MYCN-amplified neuroblastoma model.
Genome-wide assessment of AU-rich elements by the AREScore algorithm.
Milan Spasic,Caroline C. Friedel,Johanna Schott,Jochen Kreth,Kathrin Leppek,Sarah Hofmann,Sevim Ozgur,Georg Stoecklin +7 more
TL;DR: This study introduces AREScore as a simple tool to identify ARE–containing mRNAs and provides compelling evidence that AREs are widespread regulatory elements in Drosophila.
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MYCN mediates cysteine addiction and sensitizes to ferroptosis
Hamed Alborzinia,Andrés F. Flórez,Sina Gogolin,Lena M. Brückner,Chunxuan Shao,Moritz Gartlgruber,Michal Nadler-Holly,Matthias Ziehm,Franziska Paul,Sebastian Steinhauser,Emma Bell,Marjan Shaikhkarami,Sabine Hartlieb,Daniel Dreidax,Elisa M. Hess,Jochen Kreth,Gernot Poschet,Michael Büttner,Barbara Nicke,Carlo Stresemann,Jan H. Reiling,Matthias Fischer,Ido Amit,Matthias Selbach,Carl Herrmann,Stefan Wölfl,Kai-Oliver Henrich,Thomas Höfer,Frank Westermann +28 more
TL;DR: This paper showed that MYC induces massive lipid peroxidation upon depletion of cysteine, the rate-limiting amino acid for glutathione biosynthesis and sensitizes cells to ferroptosis, an oxidative, non-apoptotic and irondependent type of cell death.