Jocelyn G. Olvera
University of California, San Diego
10 Papers
Jocelyn G. Olvera is an academic researcher from University of California, San Diego. The author has contributed to research in topics: CD8 & Immune system. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Jocelyn G. Olvera include California State University San Marcos.
Chat about Author
Papers
Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses
Brigid S. Boland,Zhaoren He,Matthew S. Tsai,Jocelyn G. Olvera,Kyla D. Omilusik,Han G. Duong,Eleanor S. Kim,Abigail E. Limary,Wenhao Jin,J. Justin Milner,Bingfei Yu,Shefali Patel,Tiani L. Louis,Tiffani Tysl,Nadia S. Kurd,Alexandra Bortnick,Lauren K. Quezada,Jad N. Kanbar,Ara Miralles,Danny Huylebroeck,Danny Huylebroeck,Mark A. Valasek,Parambir S. Dulai,Siddharth Singh,Li-Fan Lu,Jack D. Bui,Cornelis Murre,William J. Sandborn,Ananda W. Goldrath,Gene W. Yeo,John T. Chang,John T. Chang +31 more
TL;DR: Together, these results provide a detailed atlas of transcriptional changes occurring in adaptive immune cells in the context of UC and suggest a role for CD8+ TRM cells in IBD.
203
Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing
Nadia S. Kurd,Zhaoren He,Tiani L. Louis,J. Justin Milner,Kyla D. Omilusik,Wenhao Jin,Matthew S. Tsai,Christella E. Widjaja,Jad N. Kanbar,Jocelyn G. Olvera,Tiffani Tysl,Lauren K. Quezada,Brigid S. Boland,Wendy Huang,Cornelis Murre,Ananda W. Goldrath,Gene W. Yeo,John T. Chang,John T. Chang +18 more
TL;DR: Examining gene expression patterns of individual CD8+ T cells in the spleen and small intestine intraepithelial lymphocyte (siIEL) compartment throughout the course of their differentiation in response to viral infection revealed previously unknown transcriptional heterogeneity within the siIEL CD8- T cell population at several stages of differentiation.
173
Integrin Activation Controls Regulatory T Cell–Mediated Peripheral Tolerance
Jane E. Klann,Stephanie H. Kim,Kelly A. Remedios,Zhaoren He,Patrick J. Metz,Justine Lopez,Tiffani Tysl,Jocelyn G. Olvera,Jailal N. G. Ablack,Joseph M. Cantor,Brigid S. Boland,Gene W. Yeo,Gene W. Yeo,Ye Zheng,Li-Fan Lu,Jack D. Bui,Mark H. Ginsberg,Brian G. Petrich,John T. Chang +18 more
TL;DR: It is shown that integrin activation plays an essential, previously unappreciated role in maintaining murine TReg cell function, and a critical role for integrin-mediated signals in controlling peripheral tolerance by virtue of maintaining Treg cell function is revealed.
Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes.
Yun Hsuan Lin,Han G. Duong,Abigail E. Limary,Eleanor S. Kim,Paul Hsu,Shefali Patel,William H. Wong,Cynthia Indralingam,Yi Liu,Priscilla Yao,Natalie R. Chiang,Sara Vandenburgh,Taylor R. Anderson,Jocelyn G. Olvera,Amir Ferry,Kennidy K Takehara,Wenhao Jin,Matthew S. Tsai,Gene W. Yeo,Ananda W. Goldrath +19 more
TL;DR: In this paper , the T-box transcription factor Eomes, which represses TRM cell formation in some tissues, exhibited unexpected context-specific regulatory roles in supporting the maintenance of established TRM cells in the small intestine, but not in the colon.
32
Skin inflammation activates intestinal stromal fibroblasts and promotes colitis
Tatsuya Dokoshi,Jason S Seidman,Kellen J. Cavagnero,Fengwu Li,Marc C. Liggins,Bryn C. Taylor,Jocelyn G. Olvera,Rob Knight,John T. Chang,Nita H. Salzman,Richard L. Gallo +10 more
TL;DR: In this paper, single-cell RNA-Seq analysis on fibroblasts from humans and mice with inflammatory bowel diseases (IBDs) was performed to explore mechanisms by which these organs communicate.
27