Joanna Warren
Garvan Institute of Medical Research
4 Papers
Joanna Warren is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Functional genomics & Zebrafish. The author has an hindex of 2, co-authored 4 publications. Previous affiliations of Joanna Warren include University of New South Wales.
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Papers
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.
Nathan W. Zammit,Nathan W. Zammit,Owen M. Siggs,Owen M. Siggs,Paul Gray,Keisuke Horikawa,David B. Langley,David B. Langley,Stacey N. Walters,Stacey N. Walters,Stephen R. Daley,Stephen R. Daley,Claudia Loetsch,Joanna Warren,Joanna Warren,Jin Yan Yap,Daniele Cultrone,Daniele Cultrone,Amanda J. Russell,Elisabeth K. Malle,Jeanette E. Villanueva,Mark J. Cowley,Mark J. Cowley,Velimir Gayevskiy,Marcel E. Dinger,Marcel E. Dinger,Robert Brink,Robert Brink,David Zahra,David Zahra,Geeta Chaudhri,Gunasegaran Karupiah,Gunasegaran Karupiah,Belinda Whittle,Carla M. Roots,Edward M. Bertram,Michiko Yamada,Yogesh Jeelall,Anselm Enders,Benjamin E. Clifton,Peter D. Mabbitt,Colin J. Jackson,Susan R. Watson,Craig N. Jenne,Craig N. Jenne,Lewis L. Lanier,Tim Wiltshire,Matthew H. Spitzer,Matthew H. Spitzer,Garry P. Nolan,Frank Schmitz,Frank Schmitz,Alan Aderem,Benjamin T. Porebski,Ashley M. Buckle,Derek W. Abbott,John B. Ziegler,Maria E. Craig,Maria E. Craig,Paul Z. Benitez-Aguirre,Juliana Teo,Stuart G. Tangye,Stuart G. Tangye,Cecile King,Cecile King,Melanie Wong,Murray P. Cox,Wilson Phung,Jia Tang,Wendy Sandoval,Ingrid E. Wertz,Daniel Christ,Daniel Christ,Christopher C. Goodnow,Christopher C. Goodnow,Shane T. Grey,Shane T. Grey +76 more
TL;DR: Genetic analyses of anatomically modern humans, extinct Denisovan hominins and mice revealed a TNFAIP3 allelic series with alterations in the encoded immune response inhibitor A20, which lower A20 activity and increase autoinflammatory responses.
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A zebrafish functional genomics model to investigate the role of human A20 variants in vivo.
Daniele Cultrone,Daniele Cultrone,Nathan W. Zammit,Nathan W. Zammit,Eleanor Self,Eleanor Self,Benno Postert,Benno Postert,Jeremy Z. R. Han,Jeremy Z. R. Han,Jacqueline Bailey,Jacqueline Bailey,Joanna Warren,Joanna Warren,David R. Croucher,David R. Croucher,Kazu Kikuchi,Kazu Kikuchi,Ozren Bogdanovic,Ozren Bogdanovic,Tatyana Chtanova,Tatyana Chtanova,Daniel Hesselson,Daniel Hesselson,Shane T. Grey,Shane T. Grey +25 more
TL;DR: An evolutionarily conserved role for TNFAIP3 in limiting inflammation in the vertebrate linage is revealed and how this function is controlled by phosphorylation is shown.
A zebrafish functional genomics model to investigate the role of human A20 variants in vivo
Daniele Cultrone,Daniele Cultrone,Nathan W. Zammit,Nathan W. Zammit,Eleanor Self,Eleanor Self,Benno Postert,Benno Postert,Jeremy Z. R. Han,Jeremy Z. R. Han,Jacqueline Bailey,Jacqueline Bailey,Joanna Warren,Joanna Warren,David R. Croucher,David R. Croucher,Kazu Kikuchi,Kazu Kikuchi,Ozren Bogdanovic,Ozren Bogdanovic,Tatyana Chtanova,Tatyana Chtanova,Daniel Hesselson,Daniel Hesselson,Shane T. Grey,Shane T. Grey +25 more
TL;DR: Development of a novel functional genomics approach that utilises the new A20-deficient zebrafish (Danio rerio) model to investigate the impact of TNFAIP3 genetic variants in vivo is reported and an evolutionarily conserved role for A20 is revealed.
Treg-mediated prolonged survival of skin allografts without immunosuppression
Nina Pilat,Mario Wiletel,Anna M. Weijler,Romy Steiner,Benedikt Mahr,Joanna Warren,Joanna Warren,Theresa M. Corpuz,Theresa M. Corpuz,Thomas Wekerle,Kylie E. Webster,Kylie E. Webster,Jonathan Sprent +12 more
TL;DR: It is shown that combining low doses of IL-2 cplxs with rapamycin and blockade of the inflammatory cytokine IL-6 leads to long-term (>75 d) survival of major histocompatibility complex-different skin allografts without the need for immunosuppression.