Joanna Birch
University of Glasgow
16 Papers
2 Citations
Joanna Birch is an academic researcher from University of Glasgow. The author has contributed to research in topics: Biology & RNA polymerase III. The author has an hindex of 9, co-authored 14 publications. Previous affiliations of Joanna Birch include University of Dundee.
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Papers
mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1.
TL;DR: It is concluded that mTOR associates with TFIIIC, is recruited to pol III–transcribed genes, and relieves their repression by Maf1, a repressor that binds and inhibits pol III.
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Pol II and its associated epigenetic marks are present at Pol III–transcribed noncoding RNA genes
Artem Barski,Iouri Chepelev,Dritan Liko,Suresh Cuddapah,Alastair B. Fleming,Joanna Birch,Kairong Cui,Robert J. White,Keji Zhao +8 more
TL;DR: It is revealed that the chromatin landscape of Pol III–transcribed genes resembles that of Pol II templates in many ways, although there are also clear differences.
FACT facilitates chromatin transcription by RNA polymerases I and III
Joanna Birch,Bertrand C-M Tan,Kostya I. Panov,Tatiana B. Panova,Jens S. Andersen,Tom Owen-Hughes,Jackie Russell,Sheng-Chung Lee,Sheng-Chung Lee,Joost C. B. M. Zomerdijk +9 more
TL;DR: These findings indicate that FACT has physiological functions in chromatin transcription by all three nuclear RNA Pols, and imply that local chromatin dynamics influence transcription of the active rRNA genes by Pol I and of Pol III‐transcribed genes.
Structure and function of ribosomal RNA gene chromatin.
TL;DR: Ch Chromatin structure is inextricably linked to rRNA gene activity, and the present review highlights recent advances in this area.
Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma
Joanna Birch,Barry J. Coull,Lindsay C. Spender,Courtney Watt,Alice Willison,Nelofer Syed,Anthony J. Chalmers,M. Kismet Hossain-Ibrahim,M. Kismet Hossain-Ibrahim,Gareth J. Inman,Gareth J. Inman +10 more
TL;DR: The targeting of TGF β signalling using a variety of approaches including the TGFβ binding protein Decorin will be highlighted as attractive therapeutic strategies.
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