Joann Teo
University of New South Wales
4 Papers
Joann Teo is an academic researcher from University of New South Wales. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 4, co-authored 4 publications.
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Papers
Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer.
Joshua A. McCarroll,Tanya Dwarte,Huricha Baigude,Jason Dang,Jason Dang,Lu Yang,Rafael B. Erlich,Kathleen Kimpton,Joann Teo,Sharon M. Sagnella,Mia C. Akerfeldt,Jie Liu,Phoebe A. Phillips,Tariq M. Rana,Tariq M. Rana,Maria Kavallaris +15 more
TL;DR: It is shown that iNOP-7 can deliver siRNA against PLK1 to NSCLC cells, and decrease cell proliferation both in vitro and in vivo, and may provide a novel therapeutic strategy for the treatment ofNSCLC as well as other cancers which aberrantly express this gene.
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Effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers.
Cyrille Boyer,Joann Teo,Phoebe A. Phillips,Rafael B. Erlich,Sharon M. Sagnella,George Sharbeen,Tanya Dwarte,Hien T. T. Duong,David Goldstein,Thomas P. Davis,Maria Kavallaris,Joshua A. McCarroll +11 more
TL;DR: These results provide the first evidence of well-defined small cationic star polymers to deliver active siRNA to both pancreatic and lung cancer cells and may be a valuable tool to inhibit key genes involved in promoting chemotherapy drug resistance and metastases.
A Rationally Optimized Nanoparticle System for the Delivery of RNA Interference Therapeutics into Pancreatic Tumors in Vivo
Joann Teo,Joshua A. McCarroll,Cyrille Boyer,Janet Youkhana,Sharon M. Sagnella,Hien T. T. Duong,Jie Liu,George Sharbeen,David Goldstein,Thomas P. Davis,Thomas P. Davis,Maria Kavallaris,Phoebe A. Phillips +12 more
TL;DR: The synthesis and physicochemical characterization of star polymers are described using reversible addition-fragmentation chain transfer polymerization (RAFT) for the delivery of siRNA to pancreatic cancer cells and it is shown that star-POEGMA polymers could readily self-assemble with si RNA to form nanoparticles.
Potential applications of nanotechnology for the diagnosis and treatment of pancreatic cancer
Joshua A. McCarroll,Joann Teo,Cyrille Boyer,David Goldstein,Maria Kavallaris,Phoebe A. Phillips +5 more
TL;DR: This review will focus on the potential applications of nanotechnology for diagnosis, imaging, and delivery of therapeutic agents for the treatment of pancreatic cancer.