Joana Ribeiro
UCL Institute of Ophthalmology
31 Papers
75 Citations
Joana Ribeiro is an academic researcher from UCL Institute of Ophthalmology. The author has contributed to research in topics: Retina & Retinal degeneration. The author has an hindex of 16, co-authored 30 publications. Previous affiliations of Joana Ribeiro include University College London.
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Papers
Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors
Anai Gonzalez-Cordero,Kamil Kruczek,Arifa Naeem,Milan Fernando,Magdalena Kloc,Joana Ribeiro,Debbie Goh,Yanai Duran,Samuel J.I. Blackford,Laura Abelleira-Hervas,Robert D. Sampson,Ian O. Shum,Matthew J. Branch,Peter Gardner,Jane C. Sowden,James W B Bainbridge,Alexander J. Smith,Emma L. West,Rachael A. Pearson,Robin R. Ali,Robin R. Ali +20 more
TL;DR: A modified 2D/3D protocol is reported for generating hPSC-derived neural retinal vesicles with well-formed ONL-like structures containing cones and rods bearing inner segments and connecting cilia, nascent outer segments, and presynaptic structures that recapitulates human photoreceptor development, allowing the isolation and transplantation of a pure population of stage-matched cones.
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Use of bioreactors for culturing human retinal organoids improves photoreceptor yields.
Patrick Ovando-Roche,Emma L. West,Matthew J. Branch,Robert D. Sampson,Milan Fernando,Peter M. G. Munro,Anastasios Georgiadis,Matteo Rizzi,Magdalena Kloc,Arifa Naeem,Joana Ribeiro,Alexander J. Smith,Anai Gonzalez-Cordero,Robin R. Ali +13 more
TL;DR: Analysis revealed that the use of bioreactors results in improved laminar stratification as well as an increase in the yield of photoreceptor cells bearing cilia and nascent outer-segment-like structures.
Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179
Koji Nishiguchi,Livia S. Carvalho,Matteo Rizzi,Kate Powell,Sophia-Martha Kleine Holthaus,Selina A. Azam,Yanai Duran,Joana Ribeiro,Ulrich F O Luhmann,James W B Bainbridge,Alexander J. Smith,Robin R. Ali +11 more
TL;DR: Gene replacement in rd1 mice that are devoid of the mutation in Gpr179 successfully restores the function of both photoreceptors and bipolar cells, which is maintained for up to 13 months.
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Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors
Joana Ribeiro,Christopher A. Procyk,Emma L. West,Michelle O’Hara-Wright,Monica F. Martins,Majid Moshtagh Khorasani,Aura Hare,Mark Basche,Milan Fernando,Debbie Goh,Neeraj Jumbo,Matteo Rizzi,Kate Powell,Menahil Tariq,Michel Michaelides,James W B Bainbridge,Alexander J. Smith,Rachael A. Pearson,Anai Gonzalez-Cordero,Robin R. Ali,Robin R. Ali +20 more
TL;DR: In this paper, human pluripotent stem cell-derived cones were transplanted into a mouse model of advanced macular degeneration to restore light-sensing cone photoreceptors.
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Epstein-Barr virus strains and variations: Geographic or disease-specific variants?
TL;DR: The current knowledge on the different EBV strains and variants and its association with different diseases is reviewed, with an increasing interest to describe possible specific disease associations.
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