Joames K. Freitas Leal
Radboud University Nijmegen
8 Papers
52 Citations
Joames K. Freitas Leal is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Red blood cell & Microvesicles. The author has an hindex of 5, co-authored 8 publications.
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Papers
Nanomechanics of Extracellular Vesicles Reveals Vesiculation Pathways
Raya Sorkin,Rick Huisjes,Filip Bošković,Daan Vorselen,Silvia Pignatelli,Yifat Ofir-Birin,Joames K. Freitas Leal,Jürgen Schiller,Debakshi Mullick,Wouter H. Roos,Giel J. C. G. M. Bosman,Neta Regev-Rudzki,Raymond M. Schiffelers,Gijs J.L. Wuite +13 more
TL;DR: An in depth atomic force microscopy force spectroscopy study of the mechanical properties of natural EVs is presented and it is found that several natural vesicles of different origin have a different composition of lipids and proteins, but similar mechanical properties.
Red Blood Cell Homeostasis: Mechanisms and Effects of Microvesicle Generation in Health and Disease
TL;DR: The contribution of RBC-derived microvesicles to inflammation, thrombosis and autoimmune reactions emphasizes the need for a better understanding of the mechanisms and consequences of microvesicle generation.
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Acetylcholinesterase provides new insights into red blood cell ageing in vivo and in vitro.
TL;DR: These findings suggest that, during RBC ageing, GPI-linked proteins and integral membrane proteins are differentially sorted and may help to understand RBC homeostasis and the effects of transfusion, especially in immunologically compromised patients.
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Red Blood Cell Homeostasis: Pharmacological Interventions to Explore Biochemical, Morphological and Mechanical Properties
Judith C. A. Cluitmans,Federica Gevi,Angela Siciliano,Alessandro Matte,Joames K. Freitas Leal,Lucia De Franceschi,Lello Zolla,Roland Brock,Merel J. W. Adjobo-Hermans,Giel J. G. C. M. Bosman +9 more
TL;DR: Red blood cells have a relatively high resistance to disturbance of membrane organization in vitro, which may reflect their capacity to withstand mechanical, oxidative and osmotic stress in vivo.
The impact of circulation in a heart-lung machine on function and survival characteristics of red blood cells.
Joames K. Freitas Leal,Harry Vermeer,Dan Lazari,Leen van Garsse,Roland Brock,Merel J. W. Adjobo-Hermans,Giel J. C. G. M. Bosman +6 more
TL;DR: Changes in key characteristics of the red blood cell aging process likely increase the susceptibility of red blood cells to the various mechanical, osmotic, and immunological stress conditions encountered during and after surgery in the patient’s circulation, and thereby contribute to the side effects of surgery.
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