This review provides the reader with the up-to-date evidence-based basis for prescribing exercise as medicine in the treatment of 26 different diseases: psychiatric diseases (depression, anxiety, stress, schizophrenia); neurological diseases (dementia, Parkinson's disease, multiple sclerosis); metabolic diseases (obesity, hyperlipidemia, metabolic syndrome, polycystic ovarian syndrome, type 2 diabetes, type 1 diabetes); cardiovascular diseases (hypertension, coronary heart disease, heart failure, cerebral apoplexy, and claudication intermittent); pulmonary diseases (chronic obstructive pulmonary disease, asthma, cystic fibrosis); musculo-skeletal disorders (osteoarthritis, osteoporosis, back pain, rheumatoid arthritis); and cancer. The effect of exercise therapy on disease pathogenesis and symptoms are given and the possible mechanisms of action are discussed. We have interpreted the scientific literature and for each disease, we provide the reader with our best advice regarding the optimal type and dose for prescription of exercise.

/pdf/exercise-as-medicine-evidence-for-prescribing-exercise-as-4ap89k53ch.pdf

Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases

Saving Mothers' Lives: Reviewing maternal deaths to make motherhood safer: 2006-2008. The Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom.

Objective To synthesise reviews investigating physical activity and depression, anxiety, self-esteem and cognitive functioning in children and adolescents and to assess the association between sedentary behaviour and mental health by performing a brief review. Methods Searches were performed in 2010. Inclusion criteria specifi ed review articles reporting chronic physical activity and at least one mental health outcome that included depression, anxiety/stress, self-esteem and cognitive functioning in children or adolescents. Results Four review articles reported evidence concerning depression, four for anxiety, three for self-esteem and seven for cognitive functioning. Nine primary studies assessed associations between sedentary behaviour and mental health. Physical activity has potentially benefi cial effects for reduced depression, but the evidence base is limited. Intervention designs are low in quality, and many reviews include cross-sectional studies. Physical activity interventions have been shown to have a small benefi cial effect for reduced anxiety, but the evidence base is limited. Physical activity can lead to improvements in self-esteem, at least in the short term. However, there is a paucity of good quality research. Reviews on physical activity and cognitive functioning have provided evidence that routine physical activity can be associated with improved cognitive performance and academic achievement, but these associations are usually small and inconsistent. Primary studies showed consistent negative associations between mental health and sedentary behaviour. Conclusions Association between physical activity and mental health in young people is evident, but research designs are often weak and effects are small to moderate. Evidence shows small but consistent associations between sedentary screen time and poorer mental health.

/pdf/physical-activity-and-mental-health-in-children-and-1vtcx3fdp7.pdf

Physical activity and mental health in children and adolescents: a review of reviews

Sedentary behaviour is associated with deleterious health outcomes, which differ from those that can be attrib- uted to a lack of moderate to vigorous physical activity. This has led to the field of ''sedentary physiology'', which may be considered as separate and distinct from exercise physiology. This paper gives an overview of this emerging area of re- search and highlights the ways that it differs from traditional exercise physiology. Definitions of key terms associated with the field of sedentary physiology and a review of the self-report and objective methods for assessing sedentary behaviour are provided. Proposed mechanisms of sedentary physiology are examined, and how they differ from those linking physi- cal activity and health are highlighted. Evidence relating to associations of sedentary behaviours with major health out- comes and the population prevalence and correlates of sedentary behaviours are reviewed. Recommendations for future research are proposed.

/pdf/physiological-and-health-implications-of-a-sedentary-55lyzvdbza.pdf

Physiological and health implications of a sedentary lifestyle

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(14)60789-3.pdf

Midwifery and quality care: findings from a new evidence-informed framework for maternal and newborn care

Some evidence that exercise has positive short-term effects on self-esteem in children and young people
Improving self-esteem may help to prevent the development of psychological and behavioural problems which are common in children and adolescents. Strong evidence exists for the benefits of exercise on physical health, but evidence for the effects of exercise on mental health is scarce. This review of trials suggests that exercise has positive short-term effects on self-esteem in children and young people, and concludes that exercise may be an important measure in improving children's self-esteem. However, the reviewers note that the trials included in the review were small-scale, and recognise the need for further well-designed research in this area.

https://onlinelibrary.wiley.com/doi/pdf/10.4073/csr.2005.4

Exercise to improve self‐esteem in children and young people

Background
The routine prophylactic administration of an uterotonic agent is an integral part of active management of the third stage of labour, helping to prevent postpartum haemorrhage (PPH). The two most widely used uterotonic agents are: ergometrine-oxytocin (Syntometrine®) (a combination of oxytocin 5 international units (iu) and ergometrine 0.5 mg) and oxytocin (Syntocinon®).

Objectives
To compare the effects of ergometrine-oxytocin with oxytocin in reducing the risk of PPH (blood loss of at least 500 ml) and other maternal and neonatal outcomes.

Search methods
We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 April 2007).

Selection criteria
Randomised trials comparing ergometrine-oxytocin use with oxytocin use in women having the third stage of labour managed actively.

Data collection and analysis
We independently assessed trial eligibility and quality and extracted data. We contacted study authors for additional information.

Main results
Six trials were included (9332 women). Compared with oxytocin, ergometrine-oxytocin was associated with a small reduction in the risk of PPH using the definition of PPH of blood loss of at least 500 ml (odds ratio 0.82, 95% confidence interval 0.71 to 0.95). This advantage was found for both a dose of 5 iu oxytocin and a dose of 10 iu oxytocin, but was greater for the lower dose. There was no difference detected between the groups using either 5 or 10 iu for the stricter definition of PPH of blood loss at least 1000 ml. Adverse effects of vomiting, nausea and hypertension were more likely to be associated with the use of ergometrine-oxytocin. When heterogeneity between trials was taken into account there were no statistically significant differences found for the other maternal or neonatal outcomes.

Authors' conclusions
The use of ergometrine-oxytocin as part of the routine active management of the third stage of labour appears to be associated with a small but statistically significant reduction in the risk of PPH when compared to oxytocin for blood loss of 500 ml or more. No statistically significant difference was observed between the groups for blood loss of 1000 ml or more. A statistically significant difference was observed in the presence of maternal side-effects, including elevation of diastolic blood pressure, vomiting and nausea, associated with ergometrine-oxytocin use compared to oxytocin use. Thus, the advantage of a reduction in the risk of PPH, between 500 and 1000 ml blood loss, needs to be weighed against the adverse side-effects associated with the use of ergometrine-oxytocin.

/pdf/prophylactic-ergometrine-oxytocin-versus-oxytocin-for-the-2fd3slhui5.pdf

Prophylactic ergometrine-oxytocin versus oxytocin for the third stage of labour.

Prophylactic ergometrine-oxytocin versus oxytocin for the third stage of labour (Cochrane Review)

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Exercise to improve self‐esteem in children and young people

Prophylactic ergometrine-oxytocin versus oxytocin for the third stage of labour.

Prophylactic ergometrine-oxytocin versus oxytocin for the third stage of labour (Cochrane Review)