Jitendra Kumar Mishra
Scripps Research Institute
27 Papers
322 Citations
Jitendra Kumar Mishra is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Amino acid & Chemistry. The author has an hindex of 11, co-authored 27 publications. Previous affiliations of Jitendra Kumar Mishra include Central Drug Research Institute.
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Papers
Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
Joanne R. Doherty,Chunying Yang,Kristen E.N. Scott,Michael D. Cameron,Mohammad Fallahi,Weimin Li,Mark A. Hall,Antonio L. Amelio,Jitendra Kumar Mishra,Fangzheng Li,Mariola Tortosa,Heide Marika Genau,Robert J. Rounbehler,Yunqi Lu,Chi V. Dang,K. Ganesh Kumar,Andrew A. Butler,Thomas D. Bannister,Andrea T. Hooper,Keziban Unsal-Kacmaz,William R. Roush,John L. Cleveland +21 more
TL;DR: This paper showed that myc oncoproteins induce genes driving aerobic glycolysis, including lactate dehydrogenase-A that generates lactate, and that elevated MCT1 levels are manifest in premalignant and neoplastic Eμ-Myc transgenic B cells and in human malignancies with myc or MYCN involvement.
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Patent
Bicyclic heteroaryls as kinase inhibitors
Yangbo Feng,Yen Ting Chen,Hampton Sessions,Jitendra Kumar Mishra,Sarwat Chowdhury,Yan Yin,Philip LoGrasso,Jun-Li Luo,Thomas D. Bannister,Thomas Schroeter +9 more
- 22 Oct 2010
TL;DR: In this article, a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase or a p70S6K kinase was presented.
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Diversity-Oriented Synthetic Approach to Naturally Abundant S-Amino Acid Based Benzannulated Enantiomerically Pure Medium Ring Heterocyclic Scaffolds Employing Inter- and Intramolecular Mitsunobu Reactions†
TL;DR: This is the first example where the Mitsunobu approach has been utilized for the construction of S-amino acid based seven- and eight-membered ring systems.
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Amino acid based enantiomerically pure 3-substituted benzofused heterocycles: A new class of antithrombotic agents.
TL;DR: A diverse group of novel medium ring heterocycles derived from naturally abundant proteinogenic amino acids were evaluated for their potency towards antithrombotic activity and it was observed that the eight-membered oxazocines ane more potent compared to the corresponding oxazepines.
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Diaryloxy methano phenanthrenes: a new class of antituberculosis agents.
Gautam Panda,Shagufta,Jitendra Kumar Mishra,Vinita Chaturvedi,Anil Srivastava,Ranjana Srivastava,Brahm S. Srivastava +6 more
TL;DR: A new series of diaryloxy methano phenanthrenes prepared through tertiary-aminoalkylations of [(methoxy-phenyl)-phenanthren-9-yl-methyl]-phenols obtained from Friedel-Crafts alkylations showed the desired activity in the range of 6.25 microg/mL in vitro and in vivo.
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