Jiong Chen
Shanghai Jiao Tong University
3 Papers
2 Citations
Jiong Chen is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Drug design & Anterior communicating artery. The author has an hindex of 2, co-authored 3 publications.
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Papers
Structure-based grafting and identification of kinase-inhibitors to target mTOR signaling pathway as potential therapeutics for glioblastoma.
TL;DR: A synthetic pipeline that integrated molecular grafting, consensus scoring, virtual screening, kinase assay and structure analysis was described to systematically profile the binding potency of various small-molecule inhibitors deposited in the protein kinase-inhibitor database against the kinase domain of mTOR successfully identified a number of structurally diverse compounds to exhibit satisfactory inhibition profile against mTOR.
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Structure-based design and confirmation of peptide ligands for neuronal polo-like kinase to promote neuroregeneration
TL;DR: Structural and energetic analysis suggested that one (PBD peptide 1) of the two peptides can bind tightly to a pocket nearby the active site of KD domain, which is thus potential as self-inhibitory peptide to target and suppress nPLK kinase activity.
2
•Journal Article
Anatomic variations in the anterior circulation of the circle of Willis in cadaveric human brains.
TL;DR: All surgical approaches should be performed after angiographic demonstrations in the anterior part of the Cycle of Willis as it demonstrates the anatomic variations of ACAC.