Jinhua Wang
Utah State University
19 Papers
346 Citations
Jinhua Wang is an academic researcher from Utah State University. The author has contributed to research in topics: Aminoglycoside & Neomycin. The author has an hindex of 11, co-authored 19 publications. Previous affiliations of Jinhua Wang include Brigham Young University & Southern Research Institute.
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Papers
Application of the synthetic aminosugars for glycodiversification: synthesis and antimicrobial studies of pyranmycin.
Bryan Elchert,Jie Li,Jinhua Wang,Yu Hui,Ravi Rai,Roger Ptak,Priscilla Ward,Jon Y. Takemoto,Mekki F. Bensaci,Cheng-Wei Tom Chang +9 more
TL;DR: Although the antibacterial activity of pyranmycins against aminoglycoside resistant bacteria is less than expected, the synthetic methodologies of utilizing a library of aminosugars can be a model for future studies of glycodiversification or glycorandomization.
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Pyranmycins, a Novel Class of Aminoglycosides with Improved Acid Stability: The SAR of d-Pyranoses on Ring III of Pyranmycin
TL;DR: The synthesis of a novel class of aminoglycosides, pyranmycins, is reported along with the structure activity relationship (SAR) of their antibacterial activity against Escherichia coli, which will lead to the future designs of p Pyranmycin against drug resistant bacteria.
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Antibacterial to antifungal conversion of neamine aminoglycosides through alkyl modification. Strategy for reviving old drugs into agrofungicides.
Cheng-Wei Tom Chang,Marina Y. Fosso,Yukie Kawasaki,Sanjib K. Shrestha,Mekki F. Bensaci,Jinhua Wang,Conrad K. Evans,Jon Y. Takemoto +7 more
TL;DR: It is shown that attachment of a C8 alkyl chain to ring III of a neamine-based aminoglycoside specifically at the 4″-O position yields a broad-spectrum fungicide (FG08) without the antibacterial properties typical for aminoliccosides.
The Synthesis of L-aminosugar and the studies of L-pyranoses on the ring III of pyranmycins.
TL;DR: It is discovered that the (4)C(1) chair conformation on ring III of pyranmycin is essential for the antibacterial activity.
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Application of glycodiversification: expedient synthesis and antibacterial evaluation of a library of kanamycin B analogues.
Jie Li,Jinhua Wang,Przemyslaw G. Czyryca,Huiwen Chang,Thomas W. Orsak,Richard Evanson,Cheng-Wei Tom Chang +6 more
TL;DR: The revealed SAR will guide future designs in developing kanamycin-type aminoglycoside antibiotics against drug-resistant bacteria.
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