Jingyu Chen
Nanjing Medical University
158 Papers
233 Citations
Jingyu Chen is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Lung transplantation & Medicine. The author has an hindex of 16, co-authored 132 publications. Previous affiliations of Jingyu Chen include China-Japan Friendship Hospital & National Health and Family Planning Commission.
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Papers
Loss of PTEN induces lung fibrosis via alveolar epithelial cell senescence depending on NF-κB activation.
TL;DR: Findings indicated that senescent AECs controlled by the PTEN/NF‐κB pathway facilitated collagen accumulation in fibroblasts, resulting in lung fibrosis, which supports the notion that as an initial step in IPF, the senescence process in A ECs may be a potential therapeutic target, and thePTEN/ NF‐κBs pathway may beA promising candidate for intervention.
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Multi-omics study of silicosis reveals the potential therapeutic targets PGD2 and TXA2.
Junling Pang,Xianmei Qi,Ya Luo,Xiaona Li,Ting Shu,Baicun Li,Mei-Yue Song,Ying Liu,Dong Wei,Jingyu Chen,Jingyu Chen,Jing Wang,Chen Wang +12 more
TL;DR: The results revealed the importance of AA metabolic reprogramming, especially PGD2 and TXA2 in the progression of silicosis, and suggested that Ramatroban may be a novel potential therapeutic drug to inhibit the progress ofsilicosis.
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Quantitative proteomic characterization of lung tissue in idiopathic pulmonary fibrosis
Yaqiong Tian,Hui Li,Yujuan Gao,Chuanmei Liu,Ting Qiu,Hongyan Wu,Mengshu Cao,Yingwei Zhang,Hui Ding,Jingyu Chen,Hourong Cai +10 more
TL;DR: This study provides a list of proteomes that were detected in IPF lung tissue by iTRAQ technology combined with LC–MS/MS and will contribute better understanding to the pathogenesis of IPF and facilitate the development of therapeutic targets.
A novel pathophysiological classification of silicosis models provides some new insights into the progression of the disease.
Zhujie Cao,Mei-Yue Song,Ying Liu,Junling Pang,Zhaoguo Li,Xianmei Qi,Ting Shu,Baicun Li,Dong Wei,Jingyu Chen,Bolun Li,Jing Wang,Chen Wang,Chen Wang +13 more
TL;DR: The progression of silicosis is identified as four stages by unsupervised clustering analysis: normal stage, inflammatory stage, progressive stage and fibrotic stage, which clarified the pathophysiological features of each stage, and provided some new insights for the progression of the disease.
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Periostin: A Potential Therapeutic Target For Pulmonary Hypertension?
Xiao-Wei Nie,Chenyou Shen,Jianxin Tan,Zhi-Yuan Wu,Wei Wang,Yuan Chen,Youai Dai,Xusheng Yang,Shugao Ye,Jingyu Chen,Jin-Song Bian,Jin-Song Bian +11 more
TL;DR: This study reveals that POSTN expression is increased in human and animal models of PH and fosters PH development via a positive feedback loop between HIF-1α and POSTN during hypoxia and proposes that manipulating POSTIN expression may be an efficacious therapeutic target in the treatment of PH.
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