Jingyi Yan
Jilin University
12 Papers
34 Citations
Jingyi Yan is an academic researcher from Jilin University. The author has contributed to research in topics: Biology & Fusion protein. The author has an hindex of 6, co-authored 9 publications.
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Papers
Cu 4 Cluster Doped Monolayer MoS 2 for CO Oxidation
TL;DR: The Cu4 doped MoS2 could be a candidate for CO oxidation with lower cost and higher activity without poisoning and corrosion problems and could be realized at room temperature (even lower).
A novel capsid-modified oncolytic recombinant adenovirus type 5 for tumor-targeting gene therapy by intravenous route
Zhen Wang,Bin Yu,Baoming Wang,Jingyi Yan,Xiao Feng,Zixuan Wang,Lizheng Wang,Haihong Zhang,Hui Wu,Jiaxin Wu,Wei Kong,Xianghui Yu +11 more
TL;DR: A novel recombinant Ad5 vector was constructed carrying the capsid protein IX modified by the tumor necrosis factor related apoptosis-inducing ligand (TRAIL), which targets tumor cells bearing high levels of its receptor far above those of normal cells.
Engineered adenovirus fiber shaft fusion homotrimer of soluble TRAIL with enhanced stability and antitumor activity.
Jingyi Yan,Lizheng Wang,Zhiqiang Wang,Baoming Wang,Rui Zhu,Jinpeng Bi,Jiaxin Wu,Haihong Zhang,Hui Wu,Bin Yu,Wei Kong,Xinzi Yu +11 more
TL;DR: The recombinant fusion TRAIL developed here displayed high specific activity in both cell-based assays in vitro and animal tests in vivo, and will serve as a foundation for a new generation of recombinant proteins suitable for use in preclinical and clinical studies and for effective combination therapies to overcome tumor resistance to TRAIL.
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Improved Stability, Antitumor Effect, and Controlled Release of Recombinant Soluble TRAIL by Combining Genetic Engineering with Coaxial Electrospinning
Bin Yu,Bin Yu,Xueping Zhang,Jingyi Yan,Dong Liu,Libo Li,Renjun Pei,Xianghui Yu,Tianyan You +8 more
- 22 May 2019
TL;DR: This work obtained a stable homotrimer via genetic engineering using the adenovirus knobless fiber motif to modify sTRAIL and engineered this new recombinant sT RAIL maintained its biological activity during the electrospinning process and exhibited a good cumulative release.
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Localization of neutralization epitopes on adenovirus fiber knob from species C.
Shuai Lang,Lizheng Wang,Zixuan Wang,Rui Zhu,Jingyi Yan,Baoming Wang,Jiaxin Wu,Haihong Zhang,Hui Wu,Yan Zhou,Wei Kong,Bin Yu,Xianghui Yu +12 more
TL;DR: The dominant neutralization epitopes were located mainly in the N-terminal part of knobs from Ad1, Ad2 and Ad5, but they seemed to be located in the C-terminals of the Ad6 knob, with some individual differences in rabbit and human populations.
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