Jingjun Lin
University of Illinois at Urbana–Champaign
15 Papers
40 Citations
Jingjun Lin is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Streptococcus pneumoniae & Mycobacterium bovis. The author has an hindex of 8, co-authored 15 publications. Previous affiliations of Jingjun Lin include China Agricultural University.
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Papers
Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity in Streptococcus pneumoniae.
TL;DR: The design and synthesis of cyclic dominant negative competence-stimulating peptide analogs capable of intercepting the competence regulon in both S. pneumoniae specificity groups with activities at the low nanomolar range are reported.
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Pseudomonas aeruginosa pyocyanin modulates mucin glycosylation with sialyl-Lewis(x) to increase binding to airway epithelial cells
Jayme L. Jeffries,Jia J,Woo-Suk Choi,Shawn Choe,Miao J,Xu Y,Xu Y,Powell R,Jingjun Lin,Zhizhou Kuang,Gaskins Hr,Gee W. Lau +11 more
TL;DR: PA secretes pyocyanin (PCN) to induce a favorable environment for chronic colonization of CF lungs by increasing the glycosylation of airway mucins with sialyl-Lewisx, a preferred binding receptor for PA.
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Exendin-4 restores airway mucus homeostasis through the GLP1R-PKA-PPARγ-FOXA2-phosphatase signaling
Woo-Suk Choi,Shawn Choe,Jingjun Lin,Michael T. Borchers,Beata Kosmider,Robert Vassallo,Andrew H. Limper,Gee W. Lau +7 more
TL;DR: Exendin-4 restored FOXA2 expression, attenuated mucin production in COPD and CF-diseased airway cells, and reduced mucin and P. aeruginosa burden in mouse lungs, which may lead to the repurposing of ExendIn-4 and other incretin mimetics to restore FoxA2 function and ultimately regulate excessive mucus in diseased airways.
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Development of a Dominant Negative Competence‐Stimulating Peptide (dnCSP) that Attenuates Streptococcus pneumoniae Infectivity in a Mouse Model of Acute Pneumonia
TL;DR: This work develops a pan‐group quorum sensing inhibitor that could effectively interact with both the pneumococcus ComD1 and ComD2 receptors and evaluates the utility of dominant‐negative CSPs (dnCSPs) in attenuating pneumococcal infectivity.
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Effects of Mycobacterium bovis on monocyte-derived macrophages from bovine tuberculosis infection and healthy cattle.
TL;DR: The existence of distinctive gene expression patterns between macrophages of healthy cattle and those exposed to BTB is demonstrated and the increase in the expression of the TLR2 gene is more significant in healthy cattle response to stimulation, and the change of IL10 gene expression is moresignificant in tuberculosis cattle.
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