Jing Zhou
Western General Hospital
3 Papers
Jing Zhou is an academic researcher from Western General Hospital. The author has contributed to research in topics: Tissue homeostasis & Actin remodeling of neurons. The author has an hindex of 2, co-authored 2 publications. Previous affiliations of Jing Zhou include Edinburgh Cancer Research Centre.
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Papers
Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth
Michael S. Samuel,Jose Lopez,Ewan J. McGhee,Daniel R. Croft,David Strachan,Paul Timpson,June Munro,Ewald Schroder,Jing Zhou,Valerie G. Brunton,Nick Barker,Hans Clevers,Owen J. Sansom,Kurt I. Anderson,Valerie M. Weaver,Michael F. Olson +15 more
TL;DR: Tumor number, growth, and progression were increased by ROCK activation, while ROCK blockade was inhibitory, implicating actomyosin-mediated cellular tension and consequent collagen deposition as significant tumor promoters.
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ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival
Georgios Kanellos,Jing Zhou,Hitesh Patel,Rachel A. Ridgway,David J. Huels,Christine B. Gurniak,Emma Sandilands,Neil O. Carragher,Owen J. Sansom,Walter Witke,Valerie G. Brunton,Margaret C. Frame +11 more
TL;DR: A pathway involving the actin-severing proteins ADF and CFL1 in regulating the dynamic turnover of contractile actin stress fibers is described, vital to prevent the nucleus from being damaged by actin contractility, in turn preserving cell survival and tissue homeostasis.
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Knockdown of Tet2 Inhibits the Myogenic Differentiation of Chicken Myoblasts Induced by Ascorbic Acid
TL;DR: In this paper , the authors showed that 5-AZAscorbic acid (also called Vitamin C, VC) strengthens the function of Tets families and directly increases DNA demethylation level to affect myogenic differentiation, but the precise regulatory mechanism of DNA methylation in chicken myogenesis remains unclear.