Jing Wu
Capital Medical University
8 Papers
20 Citations
Jing Wu is an academic researcher from Capital Medical University. The author has contributed to research in topics: Medicine & Autophagy. The author has an hindex of 4, co-authored 8 publications.
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Papers
Ferroptosis in liver disease: new insights into disease mechanisms.
TL;DR: In this paper, the authors delineate three cellular defense mechanisms against ferroptosis (GPx4 in the mitochondria and cytosol, FSP1 on plasma membrane, and DHODH in mitochondria), along with four canonical modulators of ferroPTosis (system Xc−, nuclear factor erythroid 2-related factor 2, p53, and GTP cyclohydrolase-1).
Coenzyme Q10 inhibits the activation of pancreatic stellate cells through PI3K/AKT/mTOR signaling pathway.
TL;DR: The finding suggests that CoQ10 inhibits the activation of PSCs by suppressing autophagy through activating the PI3K/AKT/mTOR signaling pathway and may act as a therapeutic agent in PSC-relating pathologies and/or anti-fibrotic approaches.
Mitofusin2, a rising star in acute-on-chronic liver failure, triggers macroautophagy via the mTOR signalling pathway
TL;DR: It is found that Mfn2 significantly attenuated ACLF, characterized by ameliorated gross appearance and microscopic histopathology of liver, and reduced serum AST, ALT, and TBIL levels.
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Mitofusin2, as a Protective Target in the Liver, Controls the Balance of Apoptosis and Autophagy in Acute-on-Chronic Liver Failure.
TL;DR: Mfn2 will provide a promising therapeutic target for patients with ACLF and play a protective role in the progression of ACLF as BNIP3-mediated signaling pathway is not the only factor associated with Mfn2 controlling the balance of apoptosis and autophagy in ACLF.
Characterization of metabolic landscape in hepatocellular carcinoma.
TL;DR: A review of recent studies that investigated the metabolic traits of HCC with a specific focus on three common metabolic alterations involving glycolysis, lipid metabolism, and glutamine addiction is provided in this paper.
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