Jing Wang
Vanderbilt University Medical Center
18 Papers
4 Citations
Jing Wang is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Chromatin & Biology. The author has an hindex of 10, co-authored 18 publications. Previous affiliations of Jing Wang include Vanderbilt University.
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Papers
lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling
Yuanyuan Lu,Xiaodi Zhao,Xiaodi Zhao,Qi Liu,Cunxi Li,Ramona Graves-Deal,Zheng Cao,Bhuminder Singh,Jeffrey L. Franklin,Jing Wang,Huaying Hu,Tian-Ying Wei,Mingli Yang,Timothy J. Yeatman,Ethan Lee,Kenyi Saito-Diaz,Scott Hinger,James G. Patton,Christine H. Chung,Stephan Emmrich,Jan-Henning Klusmann,Daiming Fan,Robert J. Coffey,Robert J. Coffey +23 more
TL;DR: These findings identify a clinically actionable, epigenetic cause of cetuximab resistance, and describe a double-negative feedback loop between MIR100HG and the transcription factor GATA6, whereby Gata6 represses MIR 100HG, but this repression is relieved by miR-125b targeting of GATA 6.
HACER: an atlas of human active enhancers to interpret regulatory variants
TL;DR: The utility of HACER is demonstrated in offering a mechanistic hypothesis to explain the association of SNP rs614367 with ER-positive breast cancer risk, exploring tumor-specific enhancers in selective MYC dysregulation and prioritizing/annotating non-coding regulatory regions targeting CCND1.
miR-302a Inhibits Metastasis and Cetuximab Resistance in Colorectal Cancer by Targeting NFIB and CD44
Lina Sun,Lina Sun,Ying Fang,Xin Wang,Yanan Han,Feng Du,Cunxi Li,Huaying Hu,Hao Liu,Qi Liu,Jing Wang,Junrong Liang,Ping Chen,Hongbin Yang,Yongzhan Nie,Kaichun Wu,Daiming Fan,Robert J. Coffey,Robert J. Coffey,Yuanyuan Lu,Xiaodi Zhao +20 more
TL;DR: The findings show that miR-302a acts as a multifaceted regulator of CRC metastasis and CTX resistance by targeting NFIB and CD44, respectively.
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Nascent RNA sequencing analysis provides insights into enhancer-mediated gene regulation
TL;DR: Nascent RNA sequencing analysis (NRSA) provides a comprehensive view of enhancer-mediated gene regulation and will greatly facilitate the usage of nascent RNA sequencing techniques and accelerate the study of enhancers-mediated regulation.
MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1.
Tessa M. Popay,Jing Wang,Clare M. Adams,Gregory C. Howard,Simona G. Codreanu,Stacy D. Sherrod,John A. McLean,Lance R. Thomas,Shelly L. Lorey,Yuichi J. Machida,April M. Weissmiller,Christine M. Eischen,Qi Liu,William P. Tansey +13 more
TL;DR: Popay et al. as mentioned in this paper showed that if anti-cancer drugs were able to target HCF-1 proteins, they could potentially reduce or even reverse the growth of tumours.