Jing Wang
Wenzhou Medical College
11 Papers
12 Citations
Jing Wang is an academic researcher from Wenzhou Medical College. The author has contributed to research in topics: Retinal pigment epithelium & Microphthalmia-associated transcription factor. The author has an hindex of 6, co-authored 9 publications. Previous affiliations of Jing Wang include Vision-Sciences, Inc..
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Papers
BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells
Juan Yang,Jing Wang,Jing Wang,Li Pan,Huirong Li,Huirong Li,Chunbao Rao,Xiaobo Zhang,Guozhen Niu,Jia Qu,Ling Hou,Ling Hou +11 more
TL;DR: Results support a model in which BMP4 induces MITF expression in pluripotent stem cells and EDN3 subsequently promotes differentiation of these MITF expressing cells along the melanocyte lineage.
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The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2.
TL;DR: It is found that α-MSH or forskolin, both of which stimulate melanogenesis, also reduceTBX2 expression, and that specific knockdown of TBX2 increases melanogenesis.
10
Global Transcriptional and Epigenetic Reconfiguration during Chemical Reprogramming of Human Retinal Pigment Epithelial Cells into Photoreceptor-like Cells
TL;DR: RPE cells can be efficiently reprogrammed into photoreceptor-like cells through defined pharmacological modulations, providing a useful cell source forPhotoreceptor generation in cell replacement therapy for retinal degenerative diseases.
Disrupting Hedgehog signaling in melanocytes by SUFU knockout leads to ocular melanocytosis and anterior segment malformation
Weizhuo Wang,Fei Li,Jing Wang,Zuimeng Liu,Meiyu Tian,Zhenhang Wang,Huirong Li,Jia Qu,Yu Chen,Ling Hou +9 more
TL;DR: Interestingly, corresponding mice were fully pigmented and showed no developmental alterations in melanocyte numbers or distribution in skin and hair follicles, however, there were ectopic melanoblasts visible in the anterior chamber of the eye that eventually displayed severe malformation.
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KIT ligand produced by limbal niche cells under control of SOX10 maintains limbal epithelial stem cell survival by activating the KIT/AKT signalling pathway
TL;DR: It is reported that the neural crest transcription factor SOX10, which is expressed in neural crest‐derived limbal niche cells (LNCs), is required for LNCs to promote survival of LESCs both in vivo and in vitro.