Jing Lei
University of Michigan
28 Papers
89 Citations
Jing Lei is an academic researcher from University of Michigan. The author has contributed to research in topics: Mesenchymal stem cell & Inflammation. The author has an hindex of 18, co-authored 28 publications.
Chat about Author
Papers
Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses
Qiong Wang,Deepti R. Nagarkar,Emily R. Bowman,Dina Schneider,Babina Gosangi,Jing Lei,Ying Zhao,Christina L. McHenry,Richai V. Burgens,David J. Miller,Umadevi S. Sajjan,Marc B. Hershenson +11 more
TL;DR: It is suggested that TLR3 and MDA5, but not RIG-I, are required for maximal sensing of RV dsRNA and that TLr3 andMDA5 signal through a common downstream signaling intermediate, IRF3.
251
Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells.
Jun Young Hong,J. Kelley Bentley,Yutein Chung,Jing Lei,Jessica Steenrod,Qiang Chen,Uma S. Sajjan,Marc B. Hershenson +7 more
TL;DR: It is suggested that early-life viral infection could contribute to asthma development by provoking age-dependent, IL-25-driven type 2 immune responses.
164
The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice.
Mingyuan Han,Charu Rajput,Jun Young Hong,Jing Lei,Joanna L. Hinde,Qian Wu,J. Kelley Bentley,Marc B. Hershenson +7 more
TL;DR: The generation of mucous metaplasia in immature RV-infected mice involves a complex interplay among the innate cytokines IL-25, IL-33, and TSLP.
130
Autocrine production of TGF-β1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells
Antonia P. Popova,Paul D. Bozyk,Adam M. Goldsmith,Marisa J. Linn,Jing Lei,J. Kelley Bentley,Marc B. Hershenson +6 more
TL;DR: It is concluded that human neonatal lung MSCs demonstrate an mRNA expression pattern characteristic of myofibroblast progenitor cells, suggesting that, in the absence of other signals, fibrosis represents the "default program" for neonatal Lung MSC gene expression.
128
Periostin is required for maximal airways inflammation and hyperresponsiveness in mice
J. Kelley Bentley,Qiang Chen,Jun Young Hong,Antonia P. Popova,Jing Lei,Bethany B. Moore,Marc B. Hershenson +6 more
TL;DR: In mice, periostin is required for maximal airways hyperresponsiveness and inflammation after HDM sensitization and challenge.