Jing He

TL;DR: Skeletal muscle of trained endurance athletes is markedly insulin sensitive and has a high oxidative capacity, despite having an elevated lipid content, according to quantitative image analysis of Oil Red O staining.

TL;DR: Although mtDNA was lower in type 2 diabetic and obese subjects, the decrement in electron transport chain activity was proportionately greater, indicating functional impairment, which may contribute to the pathogenesis of muscle insulin resistance in type 1 diabetes.

TL;DR: Inhibition of complement activation by the expression of hCD46 on the pig islets did not substantially reduce the initial loss of islet mass, but was effective in limiting antibody‐mediated rejection, which resulted in a reduced need for immunosuppression to maintain normoglycemia long‐term.

TL;DR: There was evidence of reduced islet destruction in the first hours after transplantation, compared with two series of historical controls that received identical therapy but were transplanted with islets from pigs with either no or only one genetic modification.