https://www.jstage.jst.go.jp/article/jcersj2/122/1431/122_JCSJ-R14158/_pdf

Research progress in nondoped lanthanoid silicate oxyapatites as new oxygen-ion conductors

Novel two-step processing route combining mechanical alloying and microwave hybrid sintering to fabricate dense La9.33Si2Ge4O26 for SOFCs

Lanthanum apatite is one of the most promising materials as an electrolyte for intermediate-temperature solid oxide fuel cells (IT-SOFCs) which operate close to 700 °C. Here, we report the preparation and optimization of dense La 10 AlSi 5 O 26.5 tapes obtained by the combination of tape casting technology and reaction sintering. Homogeneous concentrated mixed suspensions of La 2 O 3 , Al 2 O 3 and SiO 2 were prepared in ethanol. The effect of the solid loading, the binder content, ultrasound and the initial particle size of the materials onto the characteristics of the tapes (cracking, composition, microstructure and electrical properties) has been studied. This study paves the way for further improvement in the processing of oxyapatite electrolyte for solid oxide fuel cells.

Preparation of aluminium lanthanum oxyapatite tapes, La10AlSi5O26.5, by tape casting and reaction sintering

Study of the formation of the apatite-type phases La9.33+x(SiO4)6O2+3x/2 synthesized from a lanthanum oxycarbonate La2O2CO3

Enhanced sinterability of mechanical alloyed La9.33Si2Ge4O26 oxyapatite powders for IT-SOFC electrolytes

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

Aberrant deposition of collagen is associated with cancer development and tissue fibrosis. Proline hydroxylation, catalyzed by collagen prolyl 4-hydroxylases (C-P4Hs), is necessary for collagen maturation and secretion. Here, we try to evaluate the mechanism of the regulation of CHX on collagen maturation. Using pepsin digestion, liquid chromatograph mass spectrometry and gene knockout, we find that treatment of mouse embryonic fibroblasts with cycloheximide (CHX) increases type I collagen proline hydroxylation partially via P4HA1 and mainly via P4HA2. Western blot analysis results show that CHX treatment reduces type I collagen but does not obviously impact the level of P4HA1/2 protein in the endoplasmic reticulum, which enhances the molar ratio of P4HA1/2 to type I collagen, and coimmunoprecipitation results confirm that more P4HA1/2 can bind to each type I collagen. Since C-P4Hs possess the capability to hydroxylate proline independent of ascorbate for a few cycles, this enhanced binding between P4HA1/2 and type I collagen can partially explain how CHX stimulates type I collagen maturation.

Cycloheximide promotes type I collagen maturation mainly via collagen prolyl 4-hydroxylase subunit α2

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Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

Cycloheximide promotes type I collagen maturation mainly via collagen prolyl 4-hydroxylase subunit α2