6 Papers
Jing Du is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Small interfering RNA & Gene delivery. The author has an hindex of 6, co-authored 6 publications.
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Papers
Biodegradable Nanoparticles of mPEG-PLGA-PLL Triblock Copolymers as Novel Non-Viral Vectors for Improving siRNA Delivery and Gene Silencing
Jing Du,Ying Sun,Shi Qiusheng,Peifeng Liu,Mingjie Zhu,Chun-Hui Wang,Lianfang Du,Yourong Duan +7 more
TL;DR: It is demonstrated that biodegradable NPs of mPEG-PLGA-PLL triblock copolymers can be potentially applied as novel non-viral vectors for improving siRNA delivery and gene silencing.
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Enhanced delivery of monomethoxypoly(ethylene glycol)-poly(lactic-co-glycolic acid)-poly l-lysine nanoparticles loading platelet-derived growth factor BB small interfering RNA by ultrasound and/or microbubbles to rat retinal pigment epithelium cells.
TL;DR: A novel small interfering RNA (siRNA) delivery method based on the combined use of nanoparticles (NPs) with ultrasound (US) and/or microbubbles (MBs) was introduced in the present study and the efficacy and safety were investigated.
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Targeted siRNA delivery by anti-HER2 antibody-modified nanoparticles of mPEG-chitosan diblock copolymer.
TL;DR: Results demonstrated that anti-HER2/mPEG-CS-siRNA NPs had great potential applications as a targeted strategy for siRNA delivery, and were characterized by particle size and zeta potential analyzer, and ultraviolet–visible spectrophotometer.
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Targeted delivery of biodegradable nanoparticles with ultrasound-targeted microbubble destruction-mediated hVEGF-siRNA transfection in human PC-3 cells in vitro.
TL;DR: The efficient delivery of small interfering RNA (siRNA) via the use of biodegradable nanoparticles (NPs) made from monomethoxypoly (ethylene) and poly(lactic-co-glycolic acid)-poly-l-lysine (mPEG-PLGA-PLL) triblock copolymers shows low cytotoxicity and high gene transfection efficiency.
Enhanced delivery of biodegradable mPEG-PLGA-PLL nanoparticles loading Cy3-labelled PDGF-BB siRNA by UTMD to rat retina
TL;DR: NPs loading siRNA delivered with UTMD could more effectively down-regulate the mRNA and protein expression of PDGF‐BB than NPs plus US and Histology showed no evident tissue damage after UTMD-mediated NPs loadingSiRNA transfection.
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