Jinfan Wang
Stanford University
32 Papers
66 Citations
Jinfan Wang is an academic researcher from Stanford University. The author has contributed to research in topics: Ribosome & Translation (biology). The author has an hindex of 11, co-authored 24 publications. Previous affiliations of Jinfan Wang include Uppsala University.
Chat about Author
Papers
Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation.
Christopher P. Lapointe,Rosslyn Grosely,Alex G. Johnson,Jinfan Wang,Israel S. Fernández,Joseph D. Puglisi +5 more
TL;DR: In this article, the SARS-CoV-2 NSP1 was found to be a virulence factor that inhibits protein synthesis by directly binding the human ribosome.
168
2′- O -methylation in mRNA disrupts tRNA decoding during translation elongation
Junhong Choi,Gabriele Indrisiunaite,Hasan DeMirci,Ka Weng Ieong,Jinfan Wang,Alexey Petrov,Alexey Petrov,Arjun Prabhakar,Gideon Rechavi,Gideon Rechavi,Dan Dominissini,Dan Dominissini,Chuan He,Måns Ehrenberg,Joseph D. Puglisi +14 more
TL;DR: It is shown that 2′-O-methylation within coding regions of mRNA disrupts key steps in codon reading during cognate tRNA selection, leading to excessive rejection of cognate aminoacylated tRNAs during initial selection and proofreading.
eIF5B gates the transition from translation initiation to elongation.
Jinfan Wang,Alex G. Johnson,Christopher P. Lapointe,Junhong Choi,Arjun Prabhakar,Dong-Hua Chen,Alexey Petrov,Alexey Petrov,Joseph D. Puglisi +8 more
TL;DR: Single-molecule dynamics reveal that the GTPase activity of eukaryotic initiation factor eIF5B serves as a kinetic checkpoint for the transition from translation initiation to elongation, and how its release may be governed by a change in the conformation of the ribosome complex that triggers GTP hydrolysis.
79
RACK1 on and off the ribosome.
Alex G. Johnson,Christopher P. Lapointe,Jinfan Wang,Nicholas C. Corsepius,Junhong Choi,Gabriele Fuchs,Joseph D. Puglisi +6 more
TL;DR: Insight is shed into the biochemical basis of RPs exchange on and off a mature ribosome and tools for single-molecule analysis of human translation are provided.
eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining
Christopher P. Lapointe,Rosslyn Grosely,Masaaki Sokabe,Carlos Alvarado,Jinfan Wang,Elizabeth A. Montabana,Nancy Y. Villa,B.-S. Shin,Thomas E. Dever,Christopher S. Fraser,Israel S. Fernández,Joseph D. Puglisi +11 more
TL;DR: In this paper , single-molecule spectroscopy and structural methods using an in vitro reconstituted system to examine how the human ribosomal subunits join were combined.
44