Jin Park
Baylor College of Medicine
6 Papers
4 Citations
Jin Park is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Dentate gyrus & Medicine. The author has an hindex of 2, co-authored 4 publications.
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Papers
Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten -deficiency
Chien-Ju Chen,Martina Sgritta,Jacqunae Mays,Hongyi Zhou,Rocco Lucero,Jin Park,I-Ching Wang,Jun Hyoung Park,Benny Abraham Kaipparettu,Loredana Stoica,Paymaan Jafar-Nejad,Frank Rigo,Jeannie Chin,Jeffrey L. Noebels,Mauro Costa-Mattioli +14 more
TL;DR: It is indicated that mTORC2 is the major driver underlying the neuropathophysiology associated with Pten-deficiency, and its therapeutic reduction could represent a promising and broadly effective translational therapy for neurological disorders where mTOR signaling is dysregulated.
105
Restoring activity in the thalamic reticular nucleus improves sleep architecture and reduces Aβ accumulation in mice.
Rohan Jagirdar,Chia-Hsuan Fu,Jin Park,Brian F. Corbett,Frederik Seibt,Michael Beierlein,Jeannie Chin +6 more
TL;DR: In this paper, sleep disruptions promote increases of amyloid β (Aβ) and tau in the brain and increase Alzheimer's disease (AD) risk, but the precise mechanisms that give rise to sleep disturbances have yet to be found.
16
Persistent ∆FosB expression limits recurrent seizure activity and provides neuroprotection in the dentate gyrus of APP mice
Gabriel S. Stephens,Jin Park,Andrew Eagle,Jason C. You,Manuel Silva-Pérez,Chia-Hsuan Fu,Corey P. St. Romain,Chiho Sugimoto,Shelly A. Buffington,Mauro Costa-Mattioli,Yin Liu,AJ Robison,Jeannie Chin +12 more
TL;DR: It is demonstrated that persistent ∆FosB activity acts through discrete modes of hippocampal target gene regulation to modulate neuronal excitability, limit recurrent seizure activity, and provide neuroprotection to hippocampal dentate granule cells in APP mice.
3
Distinct patterns of dentate gyrus cell activation distinguish physiologic from aberrant stimuli.
Jason C. You,Jason C. You,Kavitha Muralidharan,Kavitha Muralidharan,Chia-Hsuan Fu,Jin Park,Umberto Tosi,Xiaohong Zhang,Jeannie Chin,Jeannie Chin +9 more
TL;DR: It is found that administration of kainic acid at a low dose (5 mg/kg) to wildtype C57BL/6 mice activated a similarly sparse number of cells in the GCL as physiologic DG stimulation by exposure to a novel, enriched environment, and indicates that intrinsic circuit properties of the DG alone may not be sufficient to support the engagement of young granule cells.
Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model.
Chia-Hsuan Fu,Daniel M. Iascone,Iraklis Petrof,Iraklis Petrof,Anupam Hazra,Xiaohong Zhang,Mark S. Pyfer,Umberto Tosi,Brian F. Corbett,Jingli Cai,Jason B. Lee,Jin Park,Lorraine Iacovitti,Helen E. Scharfman,Grigori Enikolopov,Jeannie Chin,Jeannie Chin +16 more
TL;DR: This study investigates a transgenic mouse model of AD that exhibits seizures similarly to AD patients and finds that neurogenesis is increased in early stages of disease, as spontaneous seizures became evident, but is decreased below control levels as seizures recur.