Jin-ming Li
China Medical University (PRC)
11 Papers
29 Citations
Jin-ming Li is an academic researcher from China Medical University (PRC). The author has contributed to research in topics: Chemistry & Berbamine. The author has an hindex of 4, co-authored 8 publications.
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Papers
Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder.
Aaron T. Garrison,Douglas L. Orsi,Rory A. Capstick,David Whomble,Jin-ming Li,Trever R. Carter,Andrew S. Felts,Paige N. Vinson,Allie Han,Krishma Hajari,Hyekyung P. Cho,Laura B. Teal,Madeline G. Ragland,Masoud Ghamari-Langroudi,Michael Bubser,Si-Jia Chang,Nathalie Schnetz-Boutaud,Olivier Boutaud,Anna L. Blobaum,Daniel J. Foster,Colleen M. Niswender,P. Jeffrey Conn,Craig W. Lindsley,Carrie K. Jones,Chang Hoo Han +24 more
TL;DR: In acute brain slice electrophysiology studies, VU6019650 (27b) blocked the nonselective muscarinic agonist oxotremorine-M-induced increases in neuronal firing rates of midbrain dopamine neurons in the ventral tegmental area, a part of the mesolimbic dopaminergic reward circuitry.
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A potent antiarrhythmic drug N-methyl berbamine extends the action potential through inhibiting both calcium and potassium currents.
Huiyuan Hu,Shi Zhou,Xiao-dong Sun,Yingchun Xue,Ling Yan,Sun Xuanxuan,Ming Lei,Jin-ming Li,Xiaorong Zeng,Liying Hao +9 more
TL;DR: Molecular docking was used to evaluate the binding of N-MB to CaV1.2 Ca2+ and KV11.1 K+ channels, and it was shown that the drug is a potent and natural antiarrhythmic multitarget drug that may elicit its antiarrHythmic effect through blocking both Ca2 + and K+ channel currents.
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•Journal Article
Effect of dl-praeruptorin A on calcium current in ventricular cells of guinea pig
TL;DR: The results indicated that Pra had a Ca2+ channel blocking effect, and this ingredient was an ingredient of Peucedanum praeruptorum Dunn on calcium current (ICa) in the single ventricular cells of guinea pig.
10
•Journal Article
Effects of N-methyl berbamine on delayed outward potassium current in isolated rat hepatocytes.
TL;DR: NMB was a K+ channel inhibitor and reduced Ik in a concentration-dependent manner in isolated rat hepatocytes in an attempt to understand the mechanism behind delayed outward potassium currents.
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Effects of Pd-Ia,a Component of Chinese Traditional Herb Bai-Hua Qian-Hu,on Ca2+-Current and Action Potential Duration in Single Ventricular Cells of Guinea Pig Hearts
Tian-hui Chang,Jin-ming Li,Xiao-dong Sun,Yan-feng Yu,Wan-Yu Feng,Liying Hao,Yu-Ping Wang,Ke-yi Zhang,Toru Okuyama +8 more
- 20 Sep 1993
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