Jin Li
University of Chicago
6 Papers
Jin Li is an academic researcher from University of Chicago. The author has contributed to research in topics: Gene & Enhancer. The author has an hindex of 1, co-authored 3 publications.
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Papers
Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits.
Lindsey K. Stolze,Austin C. Conklin,Michael B. Whalen,Maykel López Rodríguez,Kadri Õunap,Ilakya Selvarajan,Anu Toropainen,Tiit Örd,Jin Li,Anna Eshghi,Alice E Solomon,Yun Fang,Minna U. Kaikkonen,Casey E. Romanoski +13 more
TL;DR: The possibility that genetic predisposition for complex disease is manifested through the endothelium is supported, as over 3,000 regulatory elements whose activity is modulated by genetic variants that most frequently mutated ETS, AP-1, and NF-kB binding motifs were discovered.
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Jag1-notch4 mechanosensing drives atherosclerosis
Celine Souilhol,Xiuying Li,Lindsay Canham,Hannah Roddie,Daniela Pirri,Blanca Tardajos Ayllon,Emily V. Chambers,Mark J Dunning,Mark P. Ariaans,Jin Li,Yun Fang,Maria Fragiadaki,Victoria Ridger,Jovana Serbanovic-Canic,Sarah De Val,Sheila E. Francis,Timothy James Chico,Paul C. Evans +17 more
TL;DR: Functional studies in cultured cells and in mice with EC-specific deletion of Jag1 show that JAG1-NOTCH4 signalling drives vascular dysfunction by repressing endothelial repair, and suggest therapeutic targeting of this pathway to treat atherosclerosis.
Coronary Artery Disease risk variant dampens the expression of CALCRL by reducing HSF binding to shear stress responsive enhancer in endothelial cells
Ilakya Selvarajan,Jin Li,Petri Pölönen,Tiit Örd,Kadri Õunap,Aarthi Ravindran,Kiira Mäklin,Anu Toropainen,Lindsey K. Stolze,Stephen J. White,Casey E. Romanoski,Merja Heinäniemi,Yun Fang,Minna Kaikkonen-Määttä +13 more
TL;DR: In this paper , the role of non-coding regulatory elements carrying coronary artery disease (CAD) risk SNPs and their role in the regulation of Calcitonin receptor-like (CALCRL) expression in endothelial cells was investigated.
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Mechanosensitive super-enhancers regulate genes linked to atherosclerosis in endothelial cells
Jin Li,Jiayu Zhu,Olivia A. Gray,Débora R. Sobreira,David Wu,Ru-Ting Huang,Bernadette Miao,Noboru J. Sakabe,M. Krause,Minna U. Kaikkonen,Casey E. Romanoski,Marcelo A Nobrega,Yun Fang +12 more
TL;DR: This study employs multiomics approaches to elucidate how various flow patterns influence gene regulation in endothelial cells, pinpointing critical super-enhancers involved in mechanotransduction.
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Mechanical forces and metabolic changes cooperate to drive cellular memory and endothelial phenotypes.
TL;DR: In this article, the authors discuss the various mechanical forces endothelial cells sense in the large vessels, microvasculature, and lymphatics, and how changes in environmental mechanical forces result in changes in metabolism, which ultimately influence cell physiology, cellular memory and ultimately disease initiation and progression.