Jillian M Birch
Manchester Academic Health Science Centre
71 Papers
1.1K Citations
Jillian M Birch is an academic researcher from Manchester Academic Health Science Centre. The author has contributed to research in topics: Population & Cancer. The author has an hindex of 30, co-authored 71 publications.
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Papers
Second primary tumors in neurofibromatosis 1 patients treated for optic glioma : Substantial risks after radiotherapy
Saba Sharif,Rosalie E. Ferner,Jillian M Birch,James E. Gillespie,H. Rao Gattamaneni,Michael E. Baser,D. Gareth Evans +6 more
TL;DR: There is a significantly increased risk of second nervous system tumors in those NF1 patients who received radiotherapy for their OPGs, especially when treated in childhood, and radiotherapy should only be used if absolutely essential in children with NF1.
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Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors.
Jennifer Varley,Gail McGown,Mary R Thorncroft,Louise A James,Geoffrey P. Margison,Gill Forster,D. Gareth Evans,Martin Harris,Anna Kelsey,Jillian M Birch +9 more
TL;DR: Analysis of cases of childhood adrenocortical tumors unselected for family history and germline TP53 mutations in >80%, making this the highest known incidence of a germline mutation in a tumor-suppressor gene in any cancer, provides evidence that certain TP53 alleles confer relatively low penetrance for predisposition to the development of cancer.
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Age–incidence patterns of primary CNS tumors in children, adolescents, and adults in England
Ramandeep Singh Arora,Robert D. Alston,Tim O B Eden,Edward J. Estlin,Anthony Moran,Jillian M Birch +5 more
TL;DR: The changing patterns in the epidemiology of primary CNS tumors in these three age groups with respect to sex, tumor behavior, and histology using the current WHO classification is described.
172
Incidence and survival of childhood Langerhans cell histiocytosis in Northwest England from 1954 to 1998
Robert D. Alston,Ruth G. Tatevossian,Richard J. Q. McNally,Anna Kelsey,Jillian M Birch,Tim O B Eden +5 more
TL;DR: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of pathological LangerHans cells, for which the aetiology and pathogenesis remain largely unknown.
151
Incidence of malignant disease in childhood: a 24-year review of the Manchester Children's Tumour Registry data.
TL;DR: During the study period significant increases in incidence were seen among acute lymphoid leukaemia and epithelial tumours, and an increase in germ cell tumours approached significance.
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