Jill D. Gerber
Translational Genomics Research Institute
6 Papers
Jill D. Gerber is an academic researcher from Translational Genomics Research Institute. The author has contributed to research in topics: Genome-wide association study & Neurodegeneration. The author has an hindex of 6, co-authored 6 publications.
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Papers
Voxelwise genome-wide association study (vGWAS)
Jason L. Stein,Xue Hua,Suh Lee,April J. Ho,Alex D. Leow,Arthur W. Toga,Andrew J. Saykin,Li Shen,Tatiana Foroud,Nathan Pankratz,Matthew J. Huentelman,David Craig,Jill D. Gerber,April N. Allen,Jason J. Corneveaux,Bryan M. DeChairo,Steven G. Potkin,Michael W. Weiner,Paul M. Thompson +18 more
TL;DR: This is the first voxelwise genome wide association study to the authors' knowledge, and offers a novel method to discover genetic influences on brain structure by studying only the most associated variant at each voxels.
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A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
April J. Ho,Jason L. Stein,Xue Hua,Suh Lee,Derrek P. Hibar,Alex D. Leow,Ivo D. Dinov,Arthur W. Toga,Andrew J. Saykin,Li Shen,Tatiana Foroud,Nathan Pankratz,Matthew J. Huentelman,David Craig,Jill D. Gerber,April N. Allen,Jason J. Corneveaux,Dietrich A. Stephan,Charles DeCarli,Bryan M. DeChairo,Steven G. Potkin,Clifford R. Jack,Michael Weiner,Michael Weiner,Cyrus A. Raji,Oscar L. Lopez,James T. Becker,Owen Carmichael,Paul M. Thompson +28 more
TL;DR: 3D maps of regional brain volume differences in 206 healthy elderly subjects scanned with MRI and genotyped as part of the Alzheimer's Disease Neuroimaging Initiative reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly.
Association of CR1, CLU, and PICALM with Alzheimer’s disease in a cohort of clinically characterized and neuropathologically verified individuals
Jason J. Corneveaux,Amanda J. Myers,April N. Allen,Jeremy J. Pruzin,Manuel Ramirez,Anzhelika Engel,Mike A. Nalls,Kewei Chen,Wendy Lee,Kendria Chewning,Stephen Villa,Hunsar B. Meechoovet,Jill D. Gerber,Danielle Frost,Hollie Benson,Sean O'Reilly,Lori B. Chibnik,Joshua M. Shulman,Andrew B. Singleton,David Craig,Kendall Van Keuren-Jensen,Travis Dunckley,David A. Bennett,Philip L. De Jager,Christopher B. Heward,John Hardy,Eric M. Reiman,Matthew J. Huentelman +27 more
TL;DR: Assessment of the most replicated genetic associations for Alzheimer's disease using data generated on Affymetrix SNP 6.0 arrays confirms the well-known association with APOE single nucleotide polymorphisms (SNPs), the CLU, PICALM and CR1 SNPs recently implicated in unusually large data sets, and previously implicated CST3 and ACE SNPs.
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Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.
Jason L. Stein,Xue Hua,Jonathan H. Morra,Suh Lee,Derrek P. Hibar,April J. Ho,Alex D. Leow,Arthur W. Toga,Jae Hoon Sul,Hyun Min Kang,Eleazar Eskin,Andrew J. Saykin,Li Shen,Tatiana Foroud,Nathan Pankratz,Matthew J. Huentelman,David Craig,Jill D. Gerber,April N. Allen,Jason J. Corneveaux,Dietrich A. Stephan,Jennifer Webster,Bryan M. DeChairo,Steven G. Potkin,Clifford R. Jack,Michael Weiner,Michael Weiner,Paul M. Thompson +27 more
TL;DR: The 3D profile of temporal lobe volume differences in 742 brain MRI scans of Alzheimer's disease patients, mildly impaired, and healthy elderly subjects is mapped to reveal intense temporal lobe effects, demonstrating a negative effect on global cognitive function.
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Peripheral delivery of a ROCK inhibitor improves learning and working memory.
Matthew J. Huentelman,Dietrich A. Stephan,Joshua S. Talboom,Jason J. Corneveaux,David Reiman,Jill D. Gerber,Carol A. Barnes,Gene E. Alexander,Eric M. Reiman,Eric M. Reiman,Heather A. Bimonte-Nelson +10 more
TL;DR: This study shows that peripheral administration of the ROCK inhibitor hydroxyfasudil improves spatial learning and working memory in the rodent model and suggests the potential value of ROCK inhibition for the promotion of cognition in humans.