Jill C. Rubinstein
Yale University
28 Papers
60 Citations
Jill C. Rubinstein is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 11, co-authored 26 publications. Previous affiliations of Jill C. Rubinstein include Memorial Sloan Kettering Cancer Center.
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Papers
Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032
Jill C. Rubinstein,Mario Sznol,Anna C. Pavlick,Stephan Ariyan,Elaine Cheng,Antonella Bacchiocchi,Harriet M. Kluger,Deepak Narayan,Ruth Halaban +8 more
TL;DR: Evidence is presented that a patient bearing the BRAf V600K mutation responded remarkably to PLX4032, suggesting that clinical trials should include all patients with activating BRAF V600E/K mutations.
Survival after checkpoint inhibitors for metastatic acral, mucosal and uveal melanoma.
Nicholas D. Klemen,Melinda Wang,Jill C. Rubinstein,Kelly Olino,James Clune,Stephan Ariyan,Charles Cha,Sarah A. Weiss,Harriet M. Kluger,Mario Sznol +9 more
TL;DR: Long survival in patients with metastatic melanoma from acral, mucosal, and uveal primary tumors was associated with receipt of both anti-CTLA-4 and anti-PD-1 antibodies, and local therapy was frequently employed to control disease progression.
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Recurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice
Jill C. Rubinstein,Kayleigh Herrick-Reynolds,Catherine A. Dinauer,Raffaella A. Morotti,Daniel Solomon,Glenda G. Callender,Emily R. Christison-Lagay +6 more
TL;DR: Pediatric PTC is associated with excellent survival, although recurrence is common in patients with lateral node involvement, and predictors of recurrence are multifactorial and may be influenced by extent of disease, patient or tumor biology, and aggressiveness of resection.
34
Primary low-grade fibromyxoid sarcoma of the kidney in a child with the alternative EWSR1-CREB3L1 gene fusion.
Jill C. Rubinstein,Arjun Visa,Lei Zhang,Cristina R. Antonescu,Emily R. Christison-Lagay,Raffaella A. Morotti +5 more
TL;DR: The case of a 6-year-old boy with a deceptively bland spindle cell renal neoplasm found to harbor the EWSR1-CREB3L1 gene fusion, which is an indolent tumor with late metastatic potential and a propensity for long-term disease recurrence.
24
Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma
TL;DR: It is shown that the combination of promoter CpG content and methylation level informs the ability of decitabine treatment to up-regulate gene expression, and a classifier is built to predict gene up-regulation based on promoter methylation and C pG content, which achieves a performance of 0.77 AUC.