Jiling Sun
University of Chicago
2 Papers
Jiling Sun is an academic researcher from University of Chicago. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 2, co-authored 2 publications.
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Papers
Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules.
Mary A. Markiewicz,Cristina Girao,Joseph T. Opferman,Jiling Sun,Qinghui Hu,Alexander A. Agulnik,Colin E. Bishop,Craig B. Thompson,Philip G. Ashton-Rickardt +8 more
TL;DR: It appears that the level of T cell receptor engagement provided by transporter of antigen protein 1-dependent, self-peptide/major histocompatibility complex class I molecules is sufficient to maintain the long-term survival and functional phenotype of memory cells in the absence of persistent antigen.
Specific Recognition of Thymic Self-Peptides Induces the Positive Selection of Cytotoxic T Lymphocytes
Qinghui Hu,Carthene R. Bazemore Walker,Cristina Girao,Joseph T. Opferman,Jiling Sun,J. Shabanowitz,Donald F. Hunt,Philip G. Ashton-Rickardt +7 more
TL;DR: It is demonstrated that abundant self-peptides, purified from the H-2D(b) molecules of thymic epithelial cells, are specifically recognized during the positive selection of CD8+ T cells, implying that positive selection generates a repertoire of T cells that is weakly self-reactive.