Jiji Chen
Purdue University
12 Papers
175 Citations
Jiji Chen is an academic researcher from Purdue University. The author has contributed to research in topics: Epigenetics & Histone. The author has an hindex of 12, co-authored 12 publications.
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Papers
Gold nanorod/Fe3O4 nanoparticle "nano-pearl-necklaces" for simultaneous targeting, dual-mode imaging, and photothermal ablation of cancer cells.
TL;DR: Gold and pearls: Multifunctional nanoparticles, each composed of a single, amine-modified gold nanorod, decorated with multiple "pearls" of Fe(3)O(4) nanoparticles capped with carboxy groups, are prepared and their effectiveness in simultaneous targeting, dual-mode imaging, and photothermal ablation of breast cancer cells is demonstrated.
Nuclear Targeting Dynamics of Gold Nanoclusters for Enhanced Therapy of HER2+ Breast Cancer
TL;DR: It is suggested that the nuclear localization effect of AuNCs-Her enhances the anticancer therapeutic efficacy of Herceptin as evidenced by the induction of DNA damage.
Measurement of the Attachment and Assembly of Small Amyloid-β Oligomers on Live Cell Membranes at Physiological Concentrations Using Single-Molecule Tools
TL;DR: It is concluded that at near-physiological concentrations only the small oligomeric Aβ species are relevant, they are capable of attaching to the cell membrane, and they assemble in situ to form much larger complexes.
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Fluorescence Lifetime Cross Correlation Spectroscopy Resolves EGFR and Antagonist Interaction in Live Cells
Jiji Chen,Joseph Irudayaraj +1 more
TL;DR: This work demonstrates for the first time the applicability of fluorescence lifetime correlation spectroscopy to monitor the interaction of an antagonist antibody with the epidermal growth factor receptor (EGFR) in live cells and provides new insights in biology to understand how the antagonists influence EGFR through live cell quantification and imaging.
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Proliferating cell nuclear antigen (PCNA) is required for cell-cycle regulated silent chromatin on replicated and nonreplicated genes
Andrew P. Miller,Jiji Chen,Taichi E. Takasuka,Jennifer L. Jacobi,Paul D. Kaufman,Joseph Irudayaraj,Ann L. Kirchmaier +6 more
TL;DR: Results imply that Pol30p affects epigenetic processes by influencing the composition of chromosomal histone modifications by influence of ASF1- and CAF-1-dependent pathways.
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